The catering van in the dinner scene reads "Arkoff and Corman, Industrial Caterers", a reference to American-International Pictures producer Samuel Z. Arkoff and director Roger Corman (neither of whom was involved in the original Attack of the 50 Foot Woman (1958), which was released by Allied Artists).
While blocking a scene, a stand-in asked director Christopher Guest how much his viewfinder was. Later, he asked how much the light meter was. He continued to ask Guest how much various items cost throughout the course of the day and wrote the amounts down in a small notepad. At the end of the day he added everything up and asked Guest, "So if I had $1,800 I could be a director?" Guest said yes.
Daryl Hannah wasn't interested at first in remaking an old "Grade Z" science-fiction movie, but liked the script, and saw it as an allegory about feminism.
Paul Benedict, who plays a doctor hired to cure Nancy's gigantism, suffered for several years from acromegaly, an overproduction of growth hormone. It has been speculated that the producers knew of Benedict's former condition and that his casting was an in-joke.
Sybil Danning told Femme Fatales magazine that producer Roger Corman originally talked to her about starring in a remake of Attack of the 50 Ft. Woman in the late 1980s. She even posed for some promotional pictures, but the project never went beyond that.