Ms. Valerie Frizzle (52 episodes, 1994-1997)
Carlos Ramon (52 episodes, 1994-1997)
Wanda Li (52 episodes, 1994-1997)
Dorothy Ann (52 episodes, 1994-1997)
Keesha Franklin (52 episodes, 1994-1997)
Ralphie Tennelli (52 episodes, 1994-1997)
Phoebe Terese (52 episodes, 1994-1997)
The Producer (41 episodes, 1994-1997)
Arnold Perlstein (39 episodes, 1995-1997)
Tim (39 episodes, 1995-1997)
Arnold Perlstein / Announcer / Caller / Harry Arm (16 episodes, 1994-1996)
Tim (13 episodes, 1994)
Female Producer / Caller / Baby / Call-Taker (12 episodes, 1994-1995)
Janet Perlstein / Caller (11 episodes, 1994-1997)
Announcer / Customer / Husband / Mr. Popple / Uncle Dr. Shelby (6 episodes, 1996-1997)
Caller (6 episodes, 1996-1997)
Caller (5 episodes, 1996-1997)
Caller / Mikey Ramon (5 episodes, 1994-1997)
Mr. Ruhle / Self - Special Guest: Live Action Sequences (5 episodes, 1996-1997)
Boy / Man / Mascot (4 episodes, 1995-1997)
Boy / Caller / Student / Wayne (4 episodes, 1995-1996)
Caller / Woman (4 episodes, 1997)
Caller / Kid (3 episodes, 1994-1995)
Caller (3 episodes, 1994-1996)
Caller (3 episodes, 1995-1996)
Caller (3 episodes, 1996)
Caller (3 episodes, 1996-1997)
Caller / Tiffany (3 episodes, 1995-1997)
Dorothy Ann's Mom / NASA Woman (2 episodes, 1995)
Dr. Tennelli (2 episodes, 1994-1995)
Radius Ulna 'R.U.' Humerus / Self - Special Guest: Live Action Sequences (2 episodes, 1995-1996)
Caller (2 episodes, 1994)
Fisherman / Referee (2 episodes, 1996)
Dr. Carmina Skeledon / Self - Special Guest: Live Action Sequences (2 episodes, 1995-1996)
Mrs. Li (1 episode, 1995-1996)
Caller (2 episodes, 1995-1996)
Caller (2 episodes, 1997)
Caller / Student (2 episodes, 1997)
Caller (1 episode, 1995)
Evan Rourke (1 episode, 1995)
Logaway Larry (1 episode, 1994)
Archibald Seedplot (1 episode, 1994)
Baker (1 episode, 1994)
Cornelia C. Contralto II (1 episode, 1994)
Gerri Poveri (1 episode, 1995)
Garth Sinew (1 episode, 1996)
Inspector 47 (1 episode, 1996)
Ashlee Walker Club Dupree (1 episode, 1996)
Gen. Aranius (1 episode, 1996)
Katrina Eloise 'Murph' Murphy (1 episode, 1996)
Announcer (1 episode, 1996)
Mr. Terese (1 episode, 1995)
Mr. Perlstein (1 episode, 1995)
Caller (1 episode, 1994)
Mrs. Franklin (1 episode, 1995)
Judge (1 episode, 1995)
Mr. Ramon (1 episode, 1995)
Mom (1 episode, 1996)
Caller (1 episode, 1996)
Father (1 episode, 1994)
Harry Herp (1 episode, 1995)
Mr. Junkit (1 episode, 1995)
Switch Operator (1 episode, 1995)
Tow Truck Driver (1 episode, 1995)
(1 episode, 1996)
Self (1 episode, 1997)
Flora Whiff (1 episode, 1997)
Mr. McClean (1 episode, 1997)
Horace Scope (1 episode, 1997)
Caller (1 episode, 1997)
(1 episode, 1997)
Councilor (1 episode, 1997)
Molly Cule (1 episode, 1997)
Jake's Owner (1 episode, 1997)
Mr. Ampier (1 episode, 1997)
Bus Radio (1 episode, 1997)