Brain's nemesis, Snowball, was named after a character in George Orwell's "Animal Farm".
Pinky, are you pondering what I'm pondering?
Pinky: I think so, Brain, but then it'd be Snow White and the Seven Samurai...
The title song is accompanied visually by the words being said superimposed on scenes with Pinky and the Brain in their Lab.
The 'Nickelodeon Network' adds the 'Nickelodeon' logo into the opening credits on various objects.