The name of Shirley Holmes' nemesis, Molly Hardy, is a play on the name of her great-grand-uncle Sherlock Holmes' arch-enemy: Professor Moriarty.
Voice of Sherlock Holmes:
To the holder of this letter, my commendations. Solving the puzzle of the chest required more than considerable deductive powers. My work has consumed my life and I have produced no heir to follow in my path, but I picture you a young man of good ...