The series' popularity and critical acclaim helped launch the careers of several animators, such as Craig McCracken (The Powerpuff Girls (1998), Foster's Home for Imaginary Friends (2004)), Seth MacFarlane (Family Guy (1999), American Dad! (2005)), Butch Hartman (The Fairly OddParents (2001)), and Rob Renzetti (The Powerpuff Girls (1998), My Life as a Teenage Robot (2003)).
In your dreams, you freaky little gnome
After the credits of the 2001 season, Dexter and Dee-Dee are inside the Cartoon Network logo, Dee-Dee presses a button that makes Dexter explode.
The episode D & DD, an episode parodying the famous role-playing game Dungeons and Dragons, was changed to Sibling and Sorcery to avoid legal troubles.