There are four different versions of the theme song and there are seven different versions of the opening.

According to an interview, Brandy Norwood initially hated the name Moesha but grew to like it.

Countess Vaughn left at the end of season 4 to do the spin-off show The Parkers (1999).

Brandy, William Allen Young, Marcus T. Paulk and Lamont Bentley are the only cast members to appear in every episode of the series.

Sheryl Lee Ralph left the show early in the sixth season due to a dispute with the producers.

In quite a few episodes, as he enters the Mitchell's home, Hakeem (Lamont Bentley) calls them by another TV family name.

Became available on Netflix August 1, 2020.

The series ended on a cliffhanger.

After the success of Brandy's debut in the 1997 film Cinderella, several references of the film were made throughout the series.

The season 5 episode (Secrets and Lies) was the most controversial episode in the series. This episode in particular was later criticised by actor William Allen, who played Frank.

The school Santa Monica College was heavily mentioned throughout the series and became one of the main settings in the spin-off series The Parker's.

Shar Jackson was a recurring cast member in Season 1 and was bump up to a main cast member for the rest of the series.

After the passing of Lamont Bentley and Yvette Wilson, Brandy, Sheryl Lee Ralph, William Allen Young, Marcus T. Paulk, Ray J, Shar Jackson, and Countess Vaughn are the only surviving cast members.

The setting of the Mitchell household changed throughout most of the series.

Two actresses in the "Bring It On" franchise appear in this series. Gabrielle Union plays a cheerleader in the first season and also appears as Isis in the original Bring It On. Bree Turner plays Brenda, Moesha's college roommate, and also plays Tina in the second installment of the Bring It On franchise.

Yvette Wilson left the show after season 5 to do the shows spinoff series The Parker's reprising her role.

For the closing credits, an instrumental version of the theme song is used. Though in season one, for some episodes, a completely different instrumental was used.

Both Guest stars Andrew Keegan and Gabrielle Union starred in 10 Things I Hate About You.

Fredro Starr joined the main cast in season 2 and left after season 3, and for the remainder of the series he made several guest appearances and was credited as a guest star.

Ray J joins the main cast in season 5.

Guest star Gabrielle Union also plays a cheerleader in Bring It On (2000)

Moesha's age progresses over a 5 year span throughout the entire series.

Sheryl Lee Ralph made several guest appearances in the sixth season, her absence for most of the season was explained that her character had accepted a full-time education consulting job in Jamaica.

Through out the series Ray J played 3 different roles on the show. Charles, himself and then Dorien.