There are four different versions of the theme song and there are seven different versions of the opening.
According to an interview, Brandy Norwood initially hated the name Moesha but grew to like it.
Countess Vaughn left at the end of season 4 to do the spin-off show The Parkers (1999).
Brandy, William Allen Young, Marcus T. Paulk and Lamont Bentley are the only cast members to appear in every episode of the series.
Sheryl Lee Ralph left the show early in the sixth season due to a dispute with the producers.
In quite a few episodes, as he enters the Mitchell's home, Hakeem (Lamont Bentley) calls them by another TV family name.
After the success of Brandy's debut in the 1997 film Cinderella, several references of the film were made throughout the series.
The season 5 episode (Secrets and Lies) was the most controversial episode in the series. This episode in particular was later criticised by actor William Allen, who played Frank.
The school Santa Monica College was heavily mentioned throughout the series and became one of the main settings in the spin-off series The Parker's.
Shar Jackson was a recurring cast member in Season 1 and was bump up to a main cast member for the rest of the series.
After the passing of Lamont Bentley and Yvette Wilson, Brandy, Sheryl Lee Ralph, William Allen Young, Marcus T. Paulk, Ray J, Shar Jackson, and Countess Vaughn are the only surviving cast members.
Two actresses in the "Bring It On" franchise appear in this series. Gabrielle Union plays a cheerleader in the first season and also appears as Isis in the original Bring It On. Bree Turner plays Brenda, Moesha's college roommate, and also plays Tina in the second installment of the Bring It On franchise.
Yvette Wilson left the show after season 5 to do the shows spinoff series The Parker's reprising her role.
For the closing credits, an instrumental version of the theme song is used. Though in season one, for some episodes, a completely different instrumental was used.
Both Guest stars Andrew Keegan and Gabrielle Union starred in 10 Things I Hate About You.
Fredro Starr joined the main cast in season 2 and left after season 3, and for the remainder of the series he made several guest appearances and was credited as a guest star.