Don Johnson not only starred in the series, but co-created it and owned a percentage of it. When the show went into syndication, he did quite well financially.

The series premise was created by Don Johnson and Hunter S. Thompson. Thompson can be seen briefly as a restaurant piano player in the first two episodes.

The script that Hunter S. Thompson and Don Johnson wrote and pitched to NBC was much darker than the series ended up, and wasn't particularly suitable for prime time. In it, Nash was a drug addict who was dating the daughter of a wanted San Francisco, California mafia figure.

In one episode, Jan-Michael Vincent guest starred. An alcoholic, he was completely drunk and incoherent. The other actors pretended he was able to deliver lines as they interacted with him.

James Gammon portrayed Nick Bridges, father to Don Johnson's Nash Bridges character. In real-life, Gammon was only eight and a half years older than Johnson.

In the series finale, "Fair Game", CBS had announced the show as only the season six finale, but due to budget problems with the show, Don Johnson and CBS pulled the plug on the whole series.

According to the opening credits sequence of the first season, Nash was born on December 7, 1955. It also featured Nash's and Lisa's divorce document, according to which his full name was Nash Nicholas Bridges, and hers was Lisa Crandall Bridges. Lisa was the petitioner of their divorce, and Nash was the respondent.

"Stone Cold" Steve Austin was offered a spin-off series based on his character, Jake Cage, but turned it down to focus on his wrestling career.

Despite rumors swirling about Jaime Gomez (Evan Cortez), he decided to leave the show at the end of the fifth season, to focus on other projects.

Nash (Don Johnson) shared a playful love/hate relationship with Caitlin Cross (Yasmine Bleeth). On Miami Vice (1984), James "Sonny" Crockett (Don Johnson) shared an edgier, more intense one with pop star Caitlin Davies (Sheena Easton).

When working undercover, Nash used the alias Teddy Malone.

Richard Anthony "Cheech" Marin starred in From Dusk Till Dawn (1996), and Don Johnson starred in From Dusk Till Dawn: The Series (2014).

Philip Michael Thomas guest starred in an episode alongside Don Johnson, they both starred as partners on Miami Vice (1984).