Early in the film, Shawn Wayans's character states that his father is only a few years older than him. While poking fun at the cliches in Hollywood movies about African-Americans, this is also making fun of the fact that Cuba Gooding Jr. is only 7 years younger than Laurence Fishburne, who played father and son in Boyz n the Hood (1991). Lahmard J. Tate, who plays Ashtray's father, is less than two years older than Wayans.

A trailer for the film included the tagline, "It's the only movie released this year with fourteen words in its title"

Loc Dog warns Ashtray about how promiscuous Dashiki is, and does so by saying, "She got more kids than Ms. Wayans." That is a joke in which the actor Marlon Wayans (Loc Dog) is referring to his own mother, who has ten children. Four of them are in the movie: him, Kim Wayans (Mrs. Johnson), Shawn Wayans (Ashtray), and Keenen Ivory Wayans, who has a cameo as the mailman.

Leonette Scott (Flashback Girl), spoofs her own character (Tisha) in Boyz n the Hood (1991).

Ashtray's father is played by Lahmard J. Tate, the older brother of Larenz Tate who played O-Dog in Menace II Society (1993), one of the films being parodied.

Dashiki's home address is 6969 Penetration Avenue, a comment on her promiscuity. Loc Dog's address is 187 Drive By Boulevard.

When Ashtray and Loc Dog are being thrown against the police car, a white Ford Bronco can be seen in the background with bloody hand-prints on the side. This is a reference to OJ Simpson in the infamous Bronco chase and subsequent trial.

When Loc Dog's mother is seen putting away boxes of cereal, one box of "Tricks" cereal has a nearly naked woman on the front, and a box of "Weedies" features Dr. Dre smoking an enormous spliff. At the time of the film's production, this was a comedic prop. As of 2019, there actually is a cereal, named Weedies (yes, it's packaging looks like the General Foods Wheaties, but i this contains THC).

The mailman played by Keenen Ivory Wayans who yells "Message!" all the time not only refers to the fact that he is delivering a letter while at the same time drawing attention to a message that the movie is delivering; it also spoofs the fact that writer/director John Singleton had a small cameo as a mailman in Boyz n the Hood (1991), one of the movies being parodied.

Damon Wayans was the only member of the Wayans family not to appear in the film.

Lexie Bigham (Driving Instructor) died in a car accident in 1995, almost a month before this film's release.

There are several references throughout the movie, including Stand By Me (1986) and Back to the Future (1985). The parody's title is derived a combination of "in the hood" movies: Juice (1992), Menace II Society (1993), Boyz in the Hood (1991) and South Central (1992).

Lloyd Avery II was in an uncredited role in this as "guy in the back seat" and was also in Boyz n the Hood(1991) as the guy who shot Ricky to death. He was murdered in 2005 at age 36. At the time of his death, was serving a life sentence for a double murder at Pelican Bay Prison. His body was not discovered until two days after his death inside his cell and the chief suspect was his cell mate.

This movie is a parody on the movie "menace II society "..staring jada pinkett ...before she was known as Jada pinkett Smith .

Actor Samuel Monroe Jr. played the same part in both Don't be a Menace to South Central While Drinking Your Juice in the Hood and Menace II Society (1993) (he was the one trying to defend his cousin's honor because she was pregnant). In both, he ends up getting his face stomped into the pavement in just about the same exact way.

Omar Epps is seen briefly as "Malik", going off to college. He has the same character name, and even the same clothes, as seen in "Higher Learning" from the previous year. The shooter is poking fun at Michael Rapaport's character "Remy" from the same film.

The college sniper's list of "Brothers Trying To Make It Out of the Hood" include Ricky (from "Boyz N the Hood"), Caine (from "Menace II Society"), Radio Rahiem (from "Do the Right Thing"), and finally Malik (from "Higher Learning").