Ralph Waite (voice of Shadow) replaced Don Ameche, who died in 1993 after making the first film.
Four American Bulldogs share the role of Chance, four Golden Retrievers share Shadow, and six Himalayan cat performers carry the part of Sassy.
Laurence Fishburne was initially cast as Riley before Sinbad took over.
Throughout the film, Sassy is seen licking her paws, sometimes as a haughty commentary on the superiority of cats. For this, fish oil was placed on the paws of the cat and naturally licked off.
When Sassy runs up the stairs where she startles Mr. Seaver into tossing the laundry he is carrying. Chance ends up with underwear on his head and after shaking it free proceeds to chase Sassy into the yard. In the yard, on top of a small rise, is a child's hide and seek tunnel where Sassy takes refuge. The incorrigible Chance pushes the tunnel down the incline just to create mischief and we see Sassy running inside as if in an exercise wheel. When the tunnel stops rolling, we see Sassy emerge and stagger around, dizzy from the ride. This scene was shot in cuts. For the chase shots, the dog and cat were very comfortable working together and had a long pre-training period. Chance was given voice commands to nudge the tunnel down the slope with food as a reward. For the segment where the cat is inside, the tunnel was rolled gently and the cat walked forward as it rolled. No cat was inside when the tunnel was rolling fast. When the cat emerges, it is from a slow rocking tunnel controlled by the trainer who also used an undetectable waistband on the cat made of monofilament, which he pulled gently, making it appear as if the cat was dizzy.