The Relic (1997)

If you're looking for cinematic perfection or art, this movie is not for you. It involves a monster going on a murderous rampage through the natural history museum in Chicago. Penelope-Ann Miller plays Dr. Green, who along with her mentor, wheel-chair bound Dr. Frock (James Whitmore), and police Lt. D'Agosta (Tom Sizemore) investigates several murders that have taken place in the museum. Although one would think these murders would shut down the museum, Dr.Cuthbert (Linda Hunt), the museum director, insists that it stay open in order to hold a much needed fundraising gala. This party is the film's climax and involves Frock, D'Agosta and Green trying to kill the monster while Dr. Cuthbert, the Mayor and several guests and police attempt to wade through chest deep water in dark tunnels under the museum in order to escape (but of course there's something in the water). I would say this movie is a mix between The Poseidon Adventure and Predator. The acting is very good and is aided by the chemistry between Miller and Sizemore and veteran actors Hunt (who won best supporting actress 1983) and past best actor oscar nominee Whitmore.