A homicide detective and an anthropologist try to destroy a South American lizard-like god, who's on a people eating rampage in a Chicago museum.
A researcher at Chicago's Natural History Museum sends two crates from South America containing his findings, and when the crates arrive at the museum there appears to be very little inside. However, police discover gruesome murders on the cargo ship that supposedly brought the crates to the U.S. A murder soon takes place in the museum, and while investigating the murder, Lt. Vincent D'Agosta enlists the help of Dr. Margo Green, a researcher, at the museum. She has taken an interest in the contents of her colleague's crates. Unknown to both there is a large creature roaming the museum which is gearing itself up for a benefit reception which the city's mayor is to attend.
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