Jonathan Frakes wanted John de Lancie to reprise his role as Q, but this never panned out, much to Frakes' disappointment.

Marina Sirtis admitted that she fell asleep during the premiere.

In the scene where Captain Picard and the Admiral are in Picard's ready room, there is a cloth on the back of Picard's chair. This is the cloth given to him by the Mintakans in Star Trek: The Next Generation (1987) ("Who Watches the Watchers", season three, episode 4). An episode where Starfleet used a duck blind for anthropological purposes.

When Data is malfunctioning, Captain Picard gets him to recite Sir W.S. Gilbert and Sir Arthur Sullivan's "H.M.S. Pinafore". In the Isaac Asimov story "Runaround", a malfunctioning robot recites Gilbert and Sullivan while evading capture by his human masters. Much of Data's character is taken from Asimov's writings (such as Data's "Positronic Net", adapted from Asimov's "Positronic" brains).

The only Star Trek film until now where a Stardate is never given nor displayed at any point throughout the course of the film.

In one scene, Worf is having a nightmare. The nightmare was about a tragic event which happened to Worf on Star Trek: Deep Space Nine (1993) ("Tears of the Prophets", season six finale), which took place shortly before the events in this film.

This is the first of only two "Star Trek" films not to feature any scenes on or near Earth. The second is Star Trek Beyond (2016).

This is the first Star Trek film where all of the space shots were computer-generated.

Sir Patrick Stewart wanted his life-long friend Brian Blessed to play Admiral Dougherty. Blessed did over eight hundred hours of astronaut training at Star City in Russia, and remains the number one civilian on the wait list for the International Space Station.

Sir Patrick Stewart has said that if he, not Captain Picard, were in charge, he would have made the Bak'u leave the planet.

Following the confirmation what the climax would be for the sixth season of Star Trek: Deep Space Nine (1993), Michael Piller added a couple of lines to this film acknowledging the tragic climax, and the impact this had on Worf. Rick Berman eventually overruled this, arguing that this film would confuse audience members who did not follow the series regularly.

Although several of the cast members of Star Trek: The Next Generation (1987) have directed various episodes of the series, Jonathan Frakes is the only cast member from the series to direct any of the Next Generation-related films. He directed this film and Star Trek: First Contact (1996).

Anthony Zerbe originally auditioned for the role of Adhar Ru'afo, and was considered to be the best choice for this. However, the production team decided instead to cast him in the role of Vice Admiral Dougherty. During Zerbe's audition, instead of reading the lines provided, he recited "Dante's Inferno" before seamlessly moving into the script. Director Jonathan Frakes and the producers unanimously decided to award him the role of Dougherty.

Industrial Light & Magic had provided the visual effects for Star Trek: Generations (1994) and Star Trek: First Contact (1996), but did not return for this one, because they were busy working on Deep Impact (1998) and Star Wars: Episode I - The Phantom Menace (1999).

According to a leaked manuscript, "Fade In: The Writing of Star Trek: Insurrection" (written by Michael Piller years before his death, and never released because of studio concerns about the content of said manuscript), initial concepts for this film were far removed from the final product. The first treatment (called "Star Trek: Stardust") involved Picard and a fellow cadet named Hugh Duffy (who were friends at Starfleet Academy) meeting up after almost three decades because of different circumstances. Duffy has become a renegade who has tried to provoke a war between the Federation and the Romulan Empire, and Picard must travel to the Neutral Zone to bring him back. Picard eventually finds Duffy and risks his career to help the other officer thwart a plan by the Romulans to take over a planet housing "the fountain of youth". At the end, Picard gets arrested (and stripped of his rank) by Starfleet due to his actions during this film. The plot was similar to Heart of Darkness, and featured numerous references to various episodes of Star Trek: The Next Generation (1987).

On the Blu-ray commentary, Jonathan Frakes says that for the scene where Adhar Ru'afo (F. Murray Abraham) has his skin folded over his head, producer Rick Berman and several of the make-up artists had visited a plastic surgery clinic and watched surgeries being performed to get ideas for that particular scene.

The manual control column that Commander Riker uses to steer the Enterprise is a modified Gravis Thunderbird PC joystick.

In one scene, Captain Picard and Worf perform an operatic selection from Gilbert and Sullivan. When asked about the scene during an interview to promote this film, Sir Patrick Stewart admitted that he was actually more a huge fan of Beavis and Butt-Head (1993) and not really one of Sir W.S. Gilbert and Sir Arthur Sullivan.

This is the first time in over ten years, since Star Trek: The Next Generation (1987) ("The Neutral Zone", season one finale), that Commander Riker is without his beard. It is the first time that he is seen both with and without the beard, and the last time that he is seen beardless. Jonathan Frakes wanted to do the shaven Riker as a result of female letter requests to that effect.

This is the first appearance of the newer white Starfleet dress uniforms. They were worn several more times on Star Trek: Deep Space Nine (1993), Star Trek: Voyager (1995) and Star Trek: Nemesis (2002).

The Son'a are said to produce the narcotic ketracel-white. This was used by the Dominion to control the Jem'Hadar on Star Trek: Deep Space Nine (1993).

Captain Picard and the crew use the Captain's yacht to travel to the surface of the Ba'ku homeworld. This is the only instance in either Star Trek: The Next Generation (1987) or the films in which such a vessel is ever used, although at one point during "Samaritan Snare" (season two, episode 17), this was briefly suggested that the Captain's yacht for the Enterprise-D be used to transport Captain Picard to Starbase 515 for immediate heart surgery. On that occasion, the producers decided to use a traditional shuttlecraft instead, to cut cost.

Arnold Schwarzenegger was first offered the role of Adhar Ru'afo.

Many of the shots used in the teaser trailer, such as when the crew are grabbing the phaser rifles, and when the Enterprise-E is making a turn to engage, and when other ships are lining up to fight, the Enterprise is firing quantum torpedoes, are shots used for Star Trek: First Contact (1996). There is also a shot of the Enterprise-D from Star Trek: Generations (1994) during this trailer, from the scene in that movie when it is being attacked.

One of the sound effects used during the skin stretching scenes is that of a recharging camera flash.

The Son'a plastic surgery room was recycled into the Museum of Kyrian Heritage on Star Trek: Voyager (1995) ("Living Witness", season four, episode 23).

The U.S.S. Enterprise NCC-1701-E crew quarters, transporter room, and sickbay were redressed forms of the sets used in Star Trek: Voyager (1995). The quarters had originally been built for Star Trek: The Next Generation (1987), and portions of sickbay date back to Star Trek: The Motion Picture (1979). In addition, the bay where Picard and the Ba'ku are held by the Son'a, is a redress of Voyager's cargo bay, and the shuttlecraft used by Picard and Worf is a redress of the "Runabout" set from Star Trek: Deep Space Nine (1993). Data's shuttle interior is a redress of the Voyager shuttlecraft interior. The scene where the Admiral confronts Adhar Ru'afo uses the same set as the museum scene from Star Trek: Voyager (1995) ("Living Witness", season four, episode 23). The only differences are the colors, railings, and the furniture.

The main female guest lead of Anij was offered to Sally Field.

The film was produced simultaneously with the seventh season of Star Trek: Deep Space Nine (1993) and the fifth season of Star Trek: Voyager (1995).

All the Ba'ku buildings were created using a foam-like material cut by computer.

The film takes place shortly after the Star Trek: Deep Space Nine (1993) season six finale "Tears of the Prophets".

At 5:46, Lieutenant Curtis (two pips) orders Lieutenant Commander Data (three pips) to stand down. A lesser ranked officer would not ordinarily give an order to a higher rank; however, Lieutenant Curtis is Admiral Dougherty's attaché, and thus the admiral's voice on the planet.

Wilford Brimley and Gene Hackman were asked to play Admiral Dougherty.

In the opening sequence showing life in the Ba'ku village, the alien knife used to cut bread dough is actually an Alaskan Ulu knife.

Titles considered for this ninth entry in the Star Trek movie franchise included "Millennium" (presumably because this was the final movie of the second millennium), "Nemesis" (later co-opted for the next movie in the franchise), "Pathfinder", "Past and Future", "Transcendance", "Rebellion", "Stardust", and just plain old "IX".

Its network television premiere had been scheduled for September 16, 2001 on NBC, but was scrapped, because of the September 11th attacks.

The scene where Data walks into the lake was shot at Convict Lake in Mammoth Lakes Park (very close to Mammoth, California).

The character Gallatin was named for Gallatin County, Montana, location of the town of Bozeman, birth place of Star Trek writer Brannon Braga.

Joseph Ruskin played the roles of Galt on Star Trek: The Original Series (1966) ("The Gamesters of Triskelion", season two, episode 16), Tumek on Star Trek: Deep Space Nine (1993) ("The House of Quark", season three, episode three) and ("Looking for par'Mach in All the Wrong Places", season five, episode three), a Cardassian informant ("Improbable Cause", season three, episode 20), a Son'a officer in this film, a Vulcan Master on Star Trek: Voyager (1995) ("Gravity", season five, episode 13), and a Suliban doctor on Star Trek: Enterprise (2001) (the pilot episode "Broken Bow").

The Son'a are only ever mentioned once in the series during Star Trek: Deep Space Nine (1993). Damar discusses them in passing with Weyoun.

The film takes place in 2375.

This is the final Star Trek film to be released before the death of DeForest Kelley; Dr. Leonard "Bones" McCoy of Star Trek: The Original Series (1966).

This is the final Star Trek film to be rated PG.

Seven Samurai (1954) is speculated to be an influence behind this film. When Captain Picard learns of the Son'a and the Federation's plot to take the peaceful Ba'ku's planet for themselves and relocate the Ba'ku to another planet. Captain Picard and the Enterprise crew set out to defend the Ba'ku, who are defenseless, and stop the Federation and the Son'a from taking their planet.

Joseph Ruskin (Son'a officer) appeared on every Star Trek series except Star Trek: The Next Generation (1987) (although he did appear in this film). With the exception of Majel Barrett, who has appeared on every Star Trek series, he was the only actor to appear on all four of the series in question. Furthermore, given that Barrett only provided the computer voice on Star Trek: Voyager (1995) and Star Trek: Enterprise (2001), Ruskin was the only actor to appear on-screen in all four series mentioned above. Along with Barrett, Clint Howard, Jack Donner, and Vince Deadrick, he was one of only five actors to appear on Star Trek: The Original Series (1966) and Star Trek: Enterprise (2001). He, Barrett, and Howard appeared on Star Trek: Deep Space Nine (1993). Jonathan Frakes appeared on four series (all except Star Trek: The Original Series (1966)). Ruskin also worked on two Star Trek video games, lending his voice to Master Si'tann in Star Trek: Hidden Evil (1999) and to Admiral Nolotai and Vulcan Master N'Kal in Star Trek: Away Team (2001).

The well-known Spanish television host Anne Igartiburu was invited to participate in this film in a brief role in the Ba'ku village, but this was deleted from the final montage.

This film bears a plot similarity to Star Trek: Deep Space Nine (1993) ("Battle Lines", season one, episode 13). In that episode, Commander Sisko, Major Kira and Dr. Bashir discover that the Ennis and the Nol-Ennis are being regenerated by an alien nanotechnology in the environment of the moon, which is their penal colony. In this film, the Enterprise crew discover that on the Ba'ku homeworld, the Ba'ku can regenerate due to the planet's regenerative radiation.

The settings of this film are revisited in fan-made series such as Voyages of the USS Angeles (1999), Star Trek: Hidden Frontier (2000), Star Trek: Odyssey (2007) and Star Trek: The Helena Chronicles (2008), as well as the audio series "Star Trek: The Section 31 Files" and, to a lesser extent, "Star Trek: Lost Frontier".

Mark Deakins (Tournel) also played Turanj on Star Trek: Voyager (1995) ("The Killing Game", season four, episodes 18 & 19) and Axum ("Unimatrix Zero", season six finale).

F. Murray Abraham and Gregg Henry appeared in Scarface (1983).

As Captain Picard, Riker, Troi and Dr. Crusher ride the turbolift in dress uniforms, a display diagram can be seen showing the lift traveling through the ship both vertically and horizontally.

Captain Picard was originally going to kill Data in this film, a decision fully supported by Brent Spiner, who felt he was getting too old to play the character. This was vetoed by Patrick Stewart. Spiner's script came with a note reading "Better luck next time". See the next film Star Trek: Nemesis (2002).

In one scene, Worf wakes up from a nightmare when Captain Picard calls him on the intercom. In the backstory, Worf had a nightmare about a tragedy he suffered on Star Trek: Deep Space Nine (1993), which took place before this film. Worf's wife Lieutenant Commander Jadzia Dax was murdered by Gul Dukat.

Donna Murphy, who plays Anij, one of the forever young members of the Ba'ku, would go on to voice the villain Mother Gothel in the animated film Tangled (2010), a role where she is obsessed with eternal youth.