For a long time, it was reported that the special was never rerun because Garfield was used without the permission of his creator, Jim Davis. Garfield and Friends (1988) writer Mark Evanier stated that Davis approved of Garfield's appearance, but the special could only be shown for a limited time as part of the agreement.
Mel Blanc died in 1989, shortly before production. This was the first time Bugs Bunny and Daffy Duck were voiced by someone other than Blanc. Jeff Bergman voiced Bugs and Daffy in this production and several subsequent productions.
This was George C. Scott's debut as a voice actor, with the only other animated production he ever spoke in being The Rescuers Down Under (1990).
When shown in Germany "Cartoon All-Stars to the rescue" was shown once on every major broadcasting channel in a matter of days.
Michelangelo is the only character in this special that doesn't appear on the poster or VHS cover.
This was the 2nd time that Tigger has been voiced by Jim Cummings instead of his original voice actor Paul Winchell, after the episode "King of the Beasties" in The New Adventures of Winnie the Pooh (1988). Cummings would later voice Tigger (with the exceptions of a few season 3 episodes) for the rest of the episodes that aired after this crossover.
Wang Film Productions, the overseas animation studio, had to complete the animation in only six weeks. Animation for a 22-minute TV production typically takes 12 to 16 weeks.
Smurfette appears on the video cover-art, but does not appear in the special itself.