When the toy line attached to this series collapsed in 1990, the remaining He-Man action figures were converted to Demolition Man (1993) action figures in full armor.

Gary Chalk modeled the voice of He-Man partly after Dolph Lundgren, whom played He-Man in the 1987 film Masters of the Universe (1987).

Skeletor was modeled after British actor Tim Curry.

Battle Beyond the Stars (1980), The Terminator (1984) and Masters of the Universe (1987) were major influences behind "The New Adventures of He-Man".

The cartoon series was intended to be a continuation of Filmation's "He-Man and the Masters of the Universe" series.

Gary Chalk later provided the voices of Man-At-Arms and Whiplash for the reboot Masters of the Universe vs. the Snake Men (2002).

She-Ra, He-Man's twin sister is not mentioned or appears in the cartoon. Originally She-Ra was to appear, but Teela appeared instead. Teela appears in The New Adventures of He-Man: Once Upon a Time (1991), as she arrives on Primus in the future to help He-Man with Skeletor, Flogg and the mutants.

Flogg's helmet was modeled after Darth Vader, the antagonist of the Star Wars: Episode IV - A New Hope (1977) films.

Unlike the Filmation cartoon and the 2002 Cartoon Network reboot, Prince Adam reveals to King Randor and Queen Marlena that he is He-Man. The only time in the "He-Man" franchise.

Mattel decided to update He-Man and move him away from his barbaric origins. Science had always been a theme of the original series and in the cartoon, so Mattel brought He-Man into the world of the future with technology all around him.

In the original "He-Man" cartoon from Filmation, Skeletor had a yellow skull and a blue body. In "The New Adventures of He-Man", Skeletor has a green skull and a purple body. Unlike his Filmation incarnation, Skeletor has eyes.

Skeletor was based after Jack Nicholson's The Joker. See: Batman (1989).

The story is slightly different in the "New Adventures" mini-comics packaged with the toys. Prince Adam transforms into He-Man in front of Skeletor, revealing his secret identity and gives up the identity to remain as He-Man permanently. The explosion from the transformation damages Skeletor and he becomes a cyborg in order to survive. Also in the comics, Skeletor does not fake allegiance to Fogg and he defeats Flogg and he assumes full command of the Evil Mutants.

When the cartoon first premiered on ITV in the United Kingdom on December 24th 1990, it aired as "The New Adventures of He-Man: The Movie" which the first 3 episodes were edited together as a TV movie. Due to adverts, the TV movie was 1 hour/40 minutes long.

Battle Beyond the Stars (1980) which is a remake of The Magnificent Seven (1960) is considered a major influence behind the cartoon. Primus, a peaceful world, is under threat from Flogg and his evil mutants. Master Sebrian, the wise man on Primus, decides that they must find a great warrior, whom will help them deal with Flogg and his evil mutants. Hydro and Flipshot are sent to find that warrior and the warrior they find to help them with the crisis is He-Man.

The cartoon's premise is of a warrior whom travels forward across time to the future to fight evil. 11 years after the cartoon's premiere on American television, another cartoon about a warrior time traveling to the future Samurai Jack (2001) premiered on Cartoon Network in the United States on 10th August 2001.

Flipshot's helmet is partially influenced by Robocop's helmet in RoboCop (1987).

He-Man/Prince Adam, Skeletor, The Sorceress, King Randor, Queen Marlena and Teela are the only characters from He-Man and the Masters of the Universe (1983) to return for the cartoon.

In The New Adventures of He-Man: Quest for the Crystals (1990) Skeletor falls into a bottomless pit filled with water which he pops up and says "Some days nothing goes right." The same thing happened to Skeletor in Masters of the Universe (1987) which Skeletor fell into a bottomless pit filled with pink liquid which after the end credits, he surfaced and said "I'll Be Back!!". The extra scene was director Gary Goddard's idea as it was to set the stage for 'Masters of the Universe 2' which didn't get made due to poor Box Office results.

Prince Adam and the Primus inhabitant's clothing is based on the clothing worn by Ancient Romans. Primus is a boy's name of Latin origin meaning "first".

The "He-Man: The New Adventure" mini-comic that came with the action figures and play-sets had a different story to that of the cartoon: In the mini-comic, Skeletor tricks Hydron and Flipshot into taking him back with them to the future and Prince Adam jumps aboard their ship to warn them about Skeletor and Prince Adams transforms into He-Man in front of Hydron, Flipshot and Skeletor. During the transformation, Skeletor grabs He-Man's power sword and the blast of the transformation burns Skeletor and Skeletor repairs himself with robotic parts and Prince Adam is permanently transformed into He-Man and He-Man accepts his new mission to save Primus.

Premiered on American television 12 years before the reboot Masters of the Universe vs. the Snake Men (2002).

Man-At-Arms, Battle Cat, Orko, She-Ra, Hordak, The Evil Horde, Beast-Man, Trap Jaw, Evil Lyn don't appear in (#1.1).

Masters of the Universe (1987) is considered to be a major influence behind the cartoon. In the film, He-Man travels to Earth and Skeletor has eyes.

Some episodes that were written in the show were episodes that were never written for the Filmation series.

The Terminator (1984) has been considered to be a influence behind the cartoon. He-Man and Skeletor travel across time to Primus in the future.

R2-D2 from the Star Wars: Episode IV - A New Hope (1977) films is considered to be an influence behind UR the robot.

In the series, He-Man battles evil mutants. Garry Chalk (The voice of He-Man) previously starred in The Fly II (1989) about a young man whom becomes an insectoid mutant creature.