Lois' maiden name is Pewterschmidt.
We're officially on welfare. Come on, kids. Help me scatter garbage on the front lawn.
Stevie is shown to have teeth whenever he talks despite the multiple mentions of him having no teeth.
In the season 5 episode "Stewie Loves Lois," the end credits are rearranged to mimic the end credits of "All In The Family," complete with the show's closing theme song.
Versions of the show that air in syndication often have their commercial breaks in different places than the original network airings. This results in some rather jarring transitions that were not present in the original broadcasts, and commercials in strangely inappropriate places. One good example of this is that Peter introduced the cutaway about a secret place for his porn, then it went commercial, and the cutaway did not play until after the commercial break!