During filming at Stowe School in Buckinghamshire, where Russell Crowe's character watches his son play rugby union, one of the students asked Russell Crowe for some acting advice. After their conversation, Crowe remembered his serious interest in acting and sent him autographed posters and photos from his film, Gladiator, and wrote a letter saying, "A thousand mile journey begins with one step." The extra, Henry Cavill, went on to pursue his acting career and ultimately landed the role of Superman in Man of Steel (2013) with Russell Crowe playing his father.

Russell Crowe and Meg Ryan became romantically involved during filming. Ryan and her husband, Dennis Quaid, divorced the next year.

Will Gaffney, stand-in for David Morse, was killed in a freak accident when a truck on which he was riding suddenly turned and drove off a cliff while being filmed in Quito, Ecuador. The movie is dedicated to him.

Originally it was planned that all extras were to receive the normal pay used for American extras. But the Ecuadorian government, who could not afford to have their actors paid that well demanded that the movie pay Ecuadorian salaries.

Kessler's bible is used for two maps of the area. The main map is drawn over Luke 21-22, which talks about the return of the Son of Man (Thorne will come and save Peter Bowman). The second map has a passage marked out, Matthew 5, which discusses the wrongness of revenge and loving your neighbor.

Harrison Ford was originally offered the lead role but turned it down.

Russell Crowe mentions being in the Special Air Service Regiment in Australia, then leaving to join the British SAS because of a lack of action. Post Vietnam in Australia operational deployments were highly limited, and often soldiers went entire careers without deploying on operations. The British armed forces had more involvement internationally. This has since changed for Australia since the late 1990's

During the scene at 1:40 into the movie when he says, "these guys are my Panama crew", you can see a piece of cardboard on the wall behind with "JUST CAUSE" written on it. Operation Just Cause was a U.S. invasion of Panama to capture Manuel Noriega, military leader and drug criminal - a storyline very similar to the movie's plot.

The school bus full of children shown in the kidnapping scene are students of Colegio Aleman (German High School), a private school located outside of Quito chartered by the German government.

One of the names of the hostages on the white board in the London Office is "Idziak" - the director of photography for this film is Slawomir Idziak.

Helicopter shown at the opening credits is Polish PZL W-3 Sokol (W-3 Hawk).

The Actor portraing "Downtown 2", member of Terry's rescue team, was actually a member of the Ecuadorian Special Forces. Similarly, the actor portraing "Downtown 3" was one of the security advisors on the production, hence his excellent handling of the FN Minimi LMG during the rescue operation.

The ball cap Peter is wearing when he is kidnapped is from Rice University in Houston,Texas.

Meg Ryan was paid $15 million for her work on the film.

Meg Ryan's character is shown holding a cigarette in numerous scenes, but unlike Pamela Reed and Russell Crowe, she never actually smokes.

Most shoots encounter difficulty of some sort but the filming of Proof of Life (2000) was beset with them. They suffered frequent hailstorms, mudslides destroyed the roads to locations, 23 members of the crew came down with a case of severe altitude sickness, two volcanic eruptions and, at one point, tear gas wafting onto the set from a nearby riot.

Castle Rock wanted Taylor Hackford to shoot the film in Mexico instead of 14,000 feet above sea level in Ecuador. They changed their mind when Hackford pointed out that there were more murders per capita in Mexico than Ecuador.

During a break in filming in England Russell Crowe visited a local boy's boarding school and played a pick-up game of rugby with the students.After the game a particular student came up to him and asked him several questions about acting.That student was a very young Henry Cavill,and the two would eventually work together several years later in "Man of Steel."Both men confirmed this moment on Britain's Graham Norton Show while promoting the movie.