To stay with the 'consumer economy' tone of the film, from beginning to end there are approximately 73 companies who have product placements shown; from logos to actual items ranging in entertainment, electronics, fashion, food, hygiene, and cars. No money was received from all the product placements in the film.

Rachael Leigh Cook's singing voice was dubbed by the lead singer of the band Letters to Cleo, Kay Hanley.

Rachael Leigh Cook, Rosario Dawson, and Tara Reid had to go to a "Band Camp" for two weeks to learn how to play the instruments their characters used in order look correct on screen. However, they did not become proficient to the level that they could play effectively on the soundtrack. The actual music was supplied by studio musicians.

In the control room scene, one of the scrolling marquee messages says, "'Can't Hardly Wait' was underrated." Harry Elfont and Deborah Kaplan directed both Can't Hardly Wait (1998) and "Josie and the Pussycats".

Above the picture of the girls on one of the magazine covers the headline says that Drew Barrymore, Cameron Diaz and Lucy Liu were cast to play the band in an upcoming movie. Peter Teschner, the editor of Josie and the Pussycats was also the editor of Charlie's Angels (2000), featuring these three actresses.

The boyband are called DuJour. The phrase is French for "of the day."

Alan Cumming's character tells the girls how lucky they are to be able to go back to their 10 year high school reunion as huge successes. Three years earlier in the Romy and Michele's High School Reunion (1997) his character was the greatest success at the 10 year reunion. Likely this line was an intentional reference.

In order to preserve the wholesome image of Josie and the Pussycats, Archie Comics demand there be a scene where Josie and the Pussycats were seen brushing their teeth.

Early on, when Wyatt and Lex (the pilots of the private plane carrying boy band Du Jour), are about to escape via parachute, Wyatt enters the cockpit and says: "take the Chevy to the levee." This is a lyric from Don McLean's song "American Pie", a song commemorating the plane crash which took the lives of rockers Buddy Holly, Ritchie Valens, and The Big Bopper.

Briefly during the airplane scene, Alexandra Cabot (Missi Pyle) breaks the fourth wall. Her brother, Alexander Cabot (Paulo Costanzo) wonders why she's even on the plane. She replies "Because I was in the comic book" and when he mis-hears her she corrects herself and says "Nothing."

Tara Reid and Carson Daly started dating after meeting on set during his cameo in this film. They eventually became engaged before ending their relationship in June 2001.

The "Bubbles" in the Mega Records recording studio change from white to yellow during the course of the film. Apparently the techs could not keep the material they were made out of to stay white, so they just went with it.

Breckin Meyer, Alexander Martin, Donald Faison, and Seth Green (the members of Du Jour) had all previously appeared in Can't Hardly Wait (1998), also directed by Harry Elfont and Deborah Kaplan, with Meyer and Faison portraying band members at each other's throats. Meyer and Faison were also in Clueless (1995).

Twin sisters and horror filmmakers Jen Soska and Sylvia Soska appear uncredited as extras. This is where they met Katharine Isabelle, whom they were a fan of, and have since collaborated with on their films.

Brandy Norwood and Aaliyah were considered for the role of Valerie Brown.

Seth Green is one of the members of the boy group Du Jour. He went on to co-create Robot Chicken (2005), which has featured voice work by several other actors in the movie, including Breckin Meyer, Donald Faison, Rachael Leigh Cook, and Rosario Dawson.

According to Josie's bus pass, Riverdale is located in the 99860 zip code. This zip code is really for Mezquital del Oro in Mexico. Valerie's bus pass reads: "RTA Riverdale Transit Authority Valerie Brown 110 Glenbrooke St. Riverdale 46528" The 46,000's are in Indiana, 46528 is for Goshen, In.

Co-director Harry Elfont revealed during the film's 16th anniversary celebration in 2017 that Beyoncé, Aaliyah, and TLC's Lisa 'Left Eye' Lopes all auditioned for the film. They read Lisa 'Left Eye' Lopes twice, as she really wanted to play the role. Elfont says Beyoncé was shy and quiet, while Aaliyah was more serious and thoughtful, whereas the film is a comedy.

Film debut for Justin Chatwin.

This film would be Harry Elfont and Deborah Kaplan's last feature film as directors.

A "Family-Friendly" edited cut version of the film officially rated PG was released on DVD along with the original PG-13 theatrical cut, which omits the majority of the profanity and sexual references.

In the movie, Melody is never actually seen with a full shirt, i.e. a full neckline and sleeves. The only time she is seen in a real shirt is during flashbacks in the "Three Small Words" music sequence.

Aaliyah was considered for the role of Valerie Brown. The film features a scene of a plane crash. Eerily enough she would then die in a plane crash on August 2001 four months after this film's theatrical release.

During the scene when the girls are eating noodles in their apartment, Valerie is reading a book entitled "12 Steps To Anger Management".

Wyatt's speech that begins "So you wanna be a rock superstar" is a reference to the Cypress Hill song "(Rock) Superstar"

Tara Reid starred as the band's drummer, Melody Valentine. Not knowing how to play drums before they filmed, she needed to learn the basics so she could appear to know what she was doing behind the kit. The producers hired Drew Thomas, who was in such bands as Bold, Into Another, and Youth of Today.

Rachael Leigh Cook (Josie) and Parker Posey (Fiona) appeared in The House of Yes (1997), playing the character Jackie-O at different ages.

Parker Posey and Alan Cumming appeared in three episodes of The Good Wife (2009) together, as former married couple, Vanessa & Eli Gold respectively.

Donald Faison and Breckin Meyer previously collaborated on Clueless (1995).

Tara Reid (Melody) and Parker Posey (Fiona) share the same birthday, November 8th.

Alan Cumming (Wyatt) was the voice of Persnikitty in Garfield (2004), which starred Breckin Meyer (Marco of DuJour) as the lead human character Jon Arbuckle.

Alternate lyrics to the theme song:" Josie and the pussy don't be such a p----- Josie and the pussycats!"

Eugene Levy (himself) and Tara Reid (Melody Valentine) also appeared in American Pie (1999), American Pie (1999), and American Reunion (2012).

Alan Cumming and RLC were both previously in Get Carter (2000) one year earlier.

Originally, Fiona was supposed to have been very fat when she was younger, but Parker Posey suggested that instead Fiona have a speech impediment.

During the Total Request Live (1998) scene, the cardboard cut-outs in the "audience" feature Johnny Depp (2), Gwen Stefani (2), Christina Aguilera (2), Britney Spears, and Matt Damon. Melody defends herself with Britney and Christina, but Carson Daly hits the cut-outs with a baseball bat. Melody eventually clubs Carson with the Matt Damon cut-out and knocks him off the bleachers.