At one point, James Woods and Jennifer Lopez were supposed to appear in this.

This is Van Damme's fourth film where he plays a dual role after Double Impact (1991), Timecop (1994) and Maximum Risk (1996).

Michael Rooker played the serial killer in Henry: Portrait of a Serial Killer years before playing the cop chasing the serial killer in Replicant.

Replicant's clothes when leaving the secluded mountain lab appear to be borrowed from Ernest P Worrall.

At the secret laboratory in the forest, a helicopter randomly lands in the bushes for no apparent reason.

At the start of the movie, Van Damme lights a $20 bill on fire to ignite gasoline on a body. When he drops the bill, it has miraculously turned into a $1 bill.