Ching Tsun / Wasteland Man / City Ghoul (voice)
Vault Dweller / Cain / Nightkin / Super Mutant (voice)
(voice)
Ghoul Officer Fisher / Wasteland Mayor Richard / Vault-Tec Computer Calix (voice)
Rodger Gaire / Vault Man / Patrol Robot / Plasma Robot / Kamikaze Robot (voice)
Emerald Solo (voice) (as Jonathan Cook)
Evita Eastwood (voice)
General Simon Barnaky (voice)
Ghoul Merchant Hieronymus / Chief Scientist DuBois / Tesla Robot / Service Robot (voice)
Wasteland Doctor Vidya / Vault Elder's Daughter Mary / Nadia (voice) (as Grey DeLisle)
Ghoul Engineer Giese / Radar Thug / Drunk / Turret Robot / Sentry Robot (voice)
Wasteland Bartender Armpit / Psycho Ghoul User / Radar Torch Soldier (voice)
Horus (voice)
Harold / Cult Ghoul Thug / Cult Ghoul Soldier / Cult Ghoul Kamikaze / Wasteland Trader Jesse (voice)
Narrator (voice)
(voice) (as Dian Pershing)
Ghoul / High Priest Blake / Cyrus / Mutant Grunt / Mutant Soldier (voice)
Gammorin / Paladin Latham (voice)
General Dekker (voice)
Paladin Ziskele (voice)
Shop-Tec Vending Computer / Radar Lieutenant / Vault Security Officer Patty (voice)