Holly Aird (Dr. Wharton) was expecting her second child during season 4 which is why in season 4 her character is nearly always seen standing behind something (or someone in walking shoots) or wearing large coats and lab coats.

All the episodes were two hours long, shown as two one-hour parts on consecutive days of each week.

Trevor Eve (Det Supt Peter Boyd) & Claire Goose (DS Amelia 'Mel' Silver) also worked together on Unforgotten (2015) as Sir Phillip Cross & Ellie Greaves respectively.

Episodes 2.5 Waking the Dead: Special Relationship: Part 1 (2002) & 2.6 Waking the Dead: Special Relationship: Part 2 (2002), written by Stephen Davis and directed by David Thacker, received an International Emmy Award.

The first series secured strong ratings, with episodes 1.3 Waking the Dead: Burn Out: Part 1 (2001) & 1.4 Waking the Dead: Burn Out: Part 2 (2001), receiving 8.4 million viewers and a 38% audience share. Persistently high ratings meant the programme was recommissioned each year for either the summer or winter schedule.

In the pilot episode (Waking the Dead: Pilot: Part 1 (2000) & Waking the Dead: Pilot: Part 2 (2000)) Boyd (Trevor Eve) had a wife and baby. However by S1 (Waking the Dead: Burn Out: Part 1 (2001) & Waking the Dead: Burn Out: Part 2 (2001)) he is very much single and instead has an elder son, who is missing.

In 2018, a five-part radio prequel to the series, The Unforgiven, was broadcast on BBC Radio 4, with Sue Johnston, Claire Goose, Wil Johnson and Holly Aird reprising their roles as Dr. Grace Foley, DS Amelia 'Mel' Silver, DI Spencer Jordan & Dr. Frankie Wharton respectively. All five episodes were written by series creator Barbara Machin.

A spin-off from the series, titled The Body Farm (2011), revolving around forensic scientist Eve Lockhart (Tara Fitzgerald), was announced by the BBC in January 2011 and ran for just one series.

Tara Fitzgerald (Dr. Eve Lockhart) & Sue Johnston (Dr. Grace Foley) also worked together on Brassed Off (1996) as Gloria & Vera receptively.

Episodes 3.5 Waking the Dead: Breaking Glass: Part 1 (2003) & 3.6 Waking the Dead: Breaking Glass: Part 2 (2003), written by Stephen Davis and directed by David Thacker, received an International Emmy Award.

Episodes 3.1 Waking the Dead: Multistorey: Part 1 (2003) & 3.2 Waking the Dead: Multistorey: Part 2 (2003), written by Ed Whitmore and directed by Robert Bierman, received an International Emmy Award.

Mel (Claire Goose)'s name was originally just Mel in the Pilot episode (Waking the Dead: Pilot: Part 1 (2000) & Waking the Dead: Pilot: Part 2 (2000)). However by Series 1 (Waking the Dead: Burn Out: Part 1 (2001) & Waking the Dead: Burn Out: Part 2 (2001)) it had been extended to Amelia.

In Waking the Dead: Cold Fusion: Part 1 (2005) & Waking the Dead: Cold Fusion: Part 2 (2005), when Spence (Wil Johnson) examines the signing-in book to the building in which the CCU are housed, two of the names shown in the book are Simon Le Bon (famous as a member of Duran Duran) and Bob Carolgees (famous for his comedy act with Spit the Dog). The latter is shown as visiting Superted at the Great Big Gay Bear Company.

When Claire Goose (Amelia) left Casualty (1986) she originally asked to be killed off, but the producers refused. When she began working on this series, the same producers also began working on the show. When she decided to leave at the end of S4 she told the producers they would have to kill her off now.