Larry and Cheryl visit a friend whose husband has died. Larry likes the shirt he wore in a photo. He goes to the store later to buy it. Jeff asks Larry to invest in a new restaurant. Larry puts trash into a garbage cart and a man objects.
A drop in a phone call on a new phone is blamed for Richard Lewis' girlfriend being hit by peanut allergies a week before the Emmys. She is a Christian Scientist and refuses medicine. Larry and Richard plot to cook brownies with Benadryl.
Larry, Jeff and Ted seek a chef for the restaurant. Larry doesn't like Ted's idea. Larry searches and learns things: Cheryl has a new, male, tennis playing pal; wedding gifts a year late are rejected; club soda and salt removes all stains.
A restaurant investor has a pool party but only Larry and Jeff show. Larry uses the house toilet and gets the nanny fired. Larry suggests her to Jeff and Susie. She snaps and Susie's life is threatened. Lewis wants in a quotation book.
Larry offends Mindy Reiser, so when Wanda Sykes tells him in confidence about a prospective terrorist attack on L.A. he uses the secret to win her back, disrupting a charity gig featuring Alanis Morissette.
Larry works in New York and returns to learn his mother died and was buried in an area for criminals because she had a tattoo. He plots to get his mother moved out of the "special section" and he uses the loss to decline unwanted invites.
Jeff must leave his house because he's allergic to the guard dog Susie bought. Larry tries to get Jeff and Susie's daughter Sammy to give up the dog but she won't. He looks to please both Jeff's family and friends who also want the dog.
Wanda's new boyfriend, rapper Krazee-Eyez Killa, tells Larry a sordid secret. He also gives him a replacement jacket needed for a scene in a new Scorcese film. Meanwhile, Larry offends Susie by not taking the tour of her new house.
On Dec. 23, Larry eats some cookies in the kitchen. Turns out those cookies were a nativity scene that Cheryl's religious sister made. Since it's Christmas Eve, too late to get a replacement. Larry finds a live Nativity at a local church.
Larry loses his trust in their restaurant chef and fires him. Later, Larry accidentally injures an influential food critic who is to come to the opening. Larry apologizes to the critic who connects him to a chef with an interesting quirk.