Mark McCorkle and Bob Schooley created the show in an elevator. McCorkle looked at Bob and said, "Kim Possible: she can do anything," and Schooley replied, "Her partner is Ron Stoppable: he can't do anything."

On February 22, 2005, after three seasons and 65 episodes, the show ended production, with Kim Possible: So the Drama (2005) serving as the series finale. Due to the popularity of the series and grassroots operations by dedicated KP fans, Disney announced on November 29, 2005, that the show would be renewed for a fourth season, which debuted on Disney Channel on February 10, 2007. The series finale aired on September 7, 2007, with the airing of the one-hour-long concluding episode Kim Possible: Graduation: Part 1 (2007)/Kim Possible: Graduation: Part 2 (2007).

At the time of its run and even after its conclusion, Kim Possible (2002) was the most-watched, highly-rated, and most-beloved television show on Disney Channel, until when Phineas and Ferb (2007) came around. Kim Possible was the most tremendously successful show Disney Channel ever had after the 1990s.

Neil Patrick Harris auditioned for the role of Ron Stoppable.

The big sign outside the school changes messages every time it's seen. Usually reflecting the current plot.

Nancy Cartwright researched naked mole rats to prepare for her role as Rufus.

John Cena auditioned for the role of Ron Stoppable. When he didn't get the role he decided it was a sign from the lord himself up above to pursue a career in professional wrestling. Had he accepted, it would have been his first project with Disney.

The series pilot Kim Possible: Crush (2002) takes place after the 4th and 6th episodes, suggesting that early episodes were not aired in production order. Crush features Dr. Drakken & Shego who weren't properly introduced until Kim Possible: Tick-Tick-Tick (2002) and Kim's hair-dryer grapple-gun which was first presented to her in Kim Possible: Bueno Nacho (2002).

Despite the series' immense popularity, most of the 3rd and 4th seasons have not yet been released on DVD or Blu-Ray. But now all of the seasons are now released with Disney's Streaming Service Disney+

Kim Possible (2002) reunites Will Friedle (Ron Stoppable) and Rider Strong (Brick Flagg) after coming off of an another Disney show, Boy Meets World (1993), which was a huge success for the Walt Disney Company in the 1990s.

Dr. Drakken's real name is Drew Theodore P. Lipsky. His origin story is first explained in Kim Possible: Attack of the Killer Bebes (2002) and alluded to in many of Drakken's follow-up encounters with Kim or her father Dr. James over the course of the series.

On November 29th, 2005, the show was granted an extension of 22 episodes - a fourth season by Disney because of a months-long viewer campaign to save the show by the fans.

The town of Middleton, where most of this series' characters live and work, is an example of "Anytown, USA," with several deliberately contradictory clues to its precise location. The people of Middleton seem to be of Californian "Valley" culture, but the town is home to numerous astronomical research facilities more typical of NASA bases in Houston, Texas and Canaveral, Florida. Middleton is also within driving distance of Rocky Mountains more suited to Colorado and its immediate neighbors. A Colorado location is supported in one of the earliest episodes: in Kim Possible: The New Ron (2002), Señor Senior Senior contemplates his plan to attack Middleton while looking at a map of Middle America, and his gaze seems to be focusing on Colorado, but this is directly contradicted in other episodes. Real life townships named Middleton can be found in the American states of Alabama, Arkansas, California, Colorado, Georgia, Idaho, Illinois, Kentucky, Massachusetts, Michigan, Mississippi, New Hampshire, New York, Ohio, Oregon, Pennsylvania, Tennessee, Texas, Utah, Virginia, and Wisconsin, as well in several non-American English-speaking countries such as England, Scotland, and Australia. The gag of a generic Middleton is probably a tribute to the similarly generic "Springfield" of The Simpsons (1989), Nancy Cartwright's (Rufus) breakthrough series.

From January 2009 until 18 May 2012, the Kim Possible World Showcase Adventure was an interactive attraction in several of Epcot's World Showcase pavilions in Walt Disney World. The attraction was an electronic scavenger hunt that had guests using special "Kimmunicators" (modified cell phones) to help Kim Possible and Ron Stoppable solve a "crime" or disrupt an evil-doer's "plans for global domination." The "Kimmunicator" was able to trigger specific events within the pavilion grounds that provided clues to completing the adventure. Presented by Verizon Wireless, the Adventure was included in park admission. After closing, the Adventure's spot was taken by a similar attraction: "Disney's Phineas and Ferb (2007)'s Agent P World Showcase Adventure," which opened in June 2012.

Ron's pet naked mole rat's name Rufus and Ron's catchphrase "Rufus!" could possibly be taken from Bill & Ted's Excellent Adventure (1989).

In 2018 Disney announced a live action movie based on Kim Possible written by the series' creators Mark McCorkle and Robert Schooley, who also executive produce it.

Aside from Ron understanding him, it is unclear whether Rufus is actually able to speak words, or if the vocalizations are a production trick known as "perception filter" for the sake of the audience. This technique is often underscored in other franchises, where animals speak clearly between themselves, but then briefly shown from the perspective of humans as only making animal sounds.

The Go Tower in which the Go Team reside at is a nod to the DC Comics's Teen Titans Titan's Tower.

In the German dub of Kim Possible, Mego and Shego are voiced by Andreas and Katrin Fröhlich, real-life siblings.

In June 2022, in celebration of the show's 20th anniversary, Christy Carlson Romano and Will Friedle hosted a "Kim Possible" reunion on their podcast, "I Hear Voices". They interviewed co-creators Mark McCorkle and Bob Schooley as well as voice actors Nicole Sullivan (Shego) and John DiMaggio (Drakken), followed by a brand new scene written by McCorkle and Schooley and directed by original voice director Lisa Schaffer in which Kim and Ron are tricked into going onto Drakken and Shego's podcast.

In both Chronological and Production order Drakken has the last line in the series in Graduation Part 2 (2007). His last line was "It was a Tuesday".

Ron is the only character known to have broken the fourth wall.

Rufus originated from an earlier television series concept from Bob Schooley and Mark McCorkle. He was to be one of several characters in a series set in a petting zoo with the lead star being a platypus named Duck Williams. Rufus was then switched over to a show that focused solely on a colony of mole rats before getting recycled in Kim Possible as Ron's pet and sidekick.

Kim was initially going to be blond and have a much older appearance that was loosely based on Bob Schooley and Mark McCorkle's assistant, Jessica. The designs were considered "too old and worldly".

Recurring characters Bonnie Rockwaller and Monique are voiced by Kirsten Storms and Raven-Symoné respectively; the actresses starred in Zenon: Girl of the 21st Century (1999) and Zenon: Z3 (2004) together, both Disney Channel Original Movies.

In an article in Disney Adventures magazine, it was revealed that the design of Kim uses elements from several of the Disney Princesses, such as Ariel's red hair, Belle's brains, and Jasmine's midriff.

Before Shego's origin was explained, fans speculated that she wasn't really human and was a she-predator.

Ron Stoppable's name is a play on the word "unstoppable".

Dr. James Timothy Possible is voiced by Gary Cole, who also voiced the main title character in Adult Swim's Harvey Birdman: Attorney at Law.