Scarlett Pomers (Kyra) went into treatment for an eating disorder, and therefore only appeared in two episodes of season five. When she returned in season six, jokes were made about Kyra's absence, such as Van asking where she's been, to which Kyra replied, "I went to get something to eat."

Reba McEntire (Reba Hart) and Melissa Peterman (Barbara Jean Booker Hart) are best friends in real life.

The character of Reba was originally going to have the name "Sally," but Reba McEntire decided that because she had such a loyal fanbase from her singing career, naming the character "Reba" would help her fans connect to the show.

Reba McEntire, JoAnna Garcia Swisher, and Steve Howey are the only cast members who appeared in all one hundred twenty-five episodes.

The only time Reba said Barbra Jean was her best friend, was in the series finale, "The Kids Are Alright".

In season five, episode seven, "Have Your Cake," Brock (Christopher Rich) tells Barbra Jean that she needs to lose some weight. In real life, Melissa Peterman had given birth to a baby boy in October 2005.

JoAnna Garcia Swisher (Cheyenne) and Steve Howey (Van) appeared in a music video for Reba and Kenny Chesney's song, "Every Other Weekend" together. The two were unnamed, but played a divorced couple that share custody of their children, and exchange them every other weekend. Despite the fact that they are divorced, both characters state that they still love each other, but are unable to tell each other in front of their children, because of the questions that would arise.

Reba's real middle name is Nell, as stated on the show.

Christopher Rich and Steve Howey are the only cast members who are from Texas.

After the fifth season, when UPN merged with The WB to form The CW, the new network picked up the series for a mid-season replacement.

Reba tells Jake that she was born in McAlester, Oklahoma, Reba's real-life birthplace.

Nell Carter, who played the first family counselor, died on January 23, 2003 of a heart attack.

Jake's full name is Jake Mitchell Hart. Jake is played by Mitch Holleman.

The show had three different opening credit sequences, with same theme song in its first three seasons. New opening credits photography was done seasonally the first two seasons. Seasons four, five, and six were the same as season three.

Kyra's full name on the show is Kyra Eleanor Hart.

Reba McEntire and Christopher Rich co-starred with Kenny Rogers in The Gambler Returns: The Luck of the Draw (1991).

Reba McEntire and Melissa Peterman were both bridesmaids at JoAnna Garcia's wedding when she married professional baseball player Nick Swisher in 2010.