This is the first Scooby-Doo movie to feature Casey Kasem, Heather North, Nicole Jaffe and Frank Welker together since 1973, and the first movie to feature Heather North since 1997.
This is the last Scooby-Doo movie to feature the theme song "Scooby-Doo, Where Are You?".
In a tribute to the original series, this movie features a recreation of the 1971 zooming Hanna-Barbara logo (also known as "The Box") after the ending credits, but without the music.
The make-up of the vampire rockstars are obvious nods to real life make up wearing rockstars, Alice Cooper, David Bowie and KISS.
There is a running gag in this movie: each time Shaggy plays his guitar, a string breaks.
Scott Innes and B.J. Ward did not reprise their roles as Scooby-Doo and Velma Dinkley from the previous direct-to-video film.