In an interview at the Paley Center, Creator Ryan Murphy said that the cast didn't like season three.

Some surgery scenes had to be edited because they were just too gory. Real plastic surgeons have remarked that plastic surgery isn't as gory as this series made it appear, but that's just for show purposes.

The character of Kimber was only supposed to be on the pilot, but Creator Ryan Murphy liked Kelly Carlson's performance so much, that he kept her on the show.

The role of Sean McNamara was written specifically for Dylan Walsh.

Ryan Murphy has admitted that he created the role of Marlowe Sawyer because he wanted to work with Peter Dinklage.

A medical advisor approved the authenticity of all surgical procedures on the show. None of them are real, even though they often appeared that way. Whenever anyone said they looked real, the make-up people were flattered.

With this series, Ryan Murphy wanted to explore the superficiality of plastic surgery. He initially avoided setting the show in Los Angeles, because he didn't want celebrities to make guest appearances. But the practice eventually did move to Los Angeles in season four.

In the season two finale, titled "Joan Rivers", Julia compares Ava (Famke Janssen) to a Phoenix. In the X-Men comics, the character of Jean Grey (also played by Janssen in the X-Men film franchise) turns into a creature called "the Phoenix".

Despite playing a plastic surgeon, Julian McMahon admits he's squeamish at the sight of blood.

Joely Richardson left the series in season four to be with her family in England. Although she was listed as part of the main cast in the introduction, she only appeared in eighteen of the forty-one episodes of seasons five and six.

Dr. Christian Troy was originally named Dr. Christian Vega. The name was changed when Julian McMahon was cast in the role.

Liz was intended to be the conscience of the office.

The series had its own music video. A rare thing for a television show.

Sophia Bush (Ridley Lange) admitted in an interview that she didn't feel comfortable making the love scenes with Kate Mara (Vanessa Bartholomew).

During season one, this was the highest rated series on American basic cable, and the highest rated among the 18-49 and 25-54 age range.

Gina Russo (Jessalyn Gilsig) and Sofia Lopez (Jonathan Del Arco) were one-shot characters to begin with, but their roles were expanded due to their popularity.

In the first season, Liz (Roma Maffia) had the surname "Winters". From season two onwards, her surname has changed to "Cruz".

Elodie Keene and Craig Zisk are the only directors who worked on every season.

The stereo used while performing surgery was made by Bang & Olufsen from Denmark.

Each episode was named after a character undergoing plastic surgery in the episode.

Not very common for a television series, the writing staff remained the same during the whole show, except for Hank Chilton, who joined in season two, and Dell Chandler, who worked only in the first season.

Matt McNamara was voted online as the series' most hated character.

With the exception of Jennifer Salt, all of the writers (Ryan Murphy, Brad Falchuk, Sean Jablonski, Hank Chilton, Lyn Greene, and Richard Levine) directed episodes of the show.

The characters are based on the lives of the writers. Many people mistake the actors for their fictional counterparts.

Some of the cast and guest stars starred in films based on Marvel comics: Julian McMahon played Victor Von Doom in Fantastic Four (2005) and Fantastic 4: Rise of the Silver Surfer (2007). Sanaa Lathan played Vanessa Brooks in Blade (1998). Famke Janssen played Jean Grey in the X-Men film franchise. Peter Dinklage played Dr. Bolivar Trask in X-Men: Days of Future Past (2014). Bradley Cooper provided the voice of Rocket Raccoon in the Marvel Cinematic Universe. Kate Mara played Susan Storm in Fantastic Four (2015). J.K. Simmons played J. Jonah Jameson in the Sam Raimi Spider-Man film franchise, and Wayne Knight played Micro in Punisher: War Zone (2008).

Matt McNamara bedded Vanessa Bartholomew and Ava Moore. Famke Janssen (Ava Moore) played Jean Grey in the X-Men film franchise, and Kate Mara (Vanessa Bartolomew) played Susan Storm in Fantastic Four (2015). The films were based on Marvel comics.

The internet website had an unpopular opinion that Ava Moore was actually the hero of the series, and that from season two onwards, the show was able to evolve and continue because of her.

Season 2 was sponsored by XM Satellite Radio, and product placement for them was huge in a couple of episodes that season.

In season five, when Sean (Dylan Walsh) and Christian (Julian McMahon) appeared in "Hearts and Scalples", they insisted on producer credits and the occasional line, this was an inside joke after Linda Klein, a producer, who also starred as Nurse Linda with the occasional line.

The series could have ended with the death of Matt McNamara (John Hensley), instead of leaving on a plane with Ava Moore (Famke Janssen). It could have ended with Matt being murdered by Christian (Julian McMahon), or Matt committing suicide, when Ava tells him she doesn't really love him. But both were rejected.

Fans of the series were underwhelmed about the finale of the series, and John Hensley (Matt McNamara) described the finale as "anti-climatic", and "I was craving for there to be some great twist", and also felt "let down" when Matt ran away with Ava, saying that it was "not really explained".