- One character is an alcoholic, and is rarely shown without a d ink in early episodes, and is even put in rehab.
- Varying drugs are shown and used, ranging from pot to pills.
- In an early episode, a character is asked to buy medical marijuana for his girlfriend, and there are numerous references to how the banana stand looks like a big roll of pot, and inspired a song, as well as a character giving another pot for $100, after commenting that you can't get good weed for $100, and the character refuses. He is later then shown smoking it.
- One character is caught in a vicious pill circle, where he takes a pill to forget a night, but forgets that he took a pill to forget the night he tried to forget, and the narrator mentions he made an order for this over 500 times.