The montage of Sarah's boyfriends are actually men whom Asia met and dated during filming. At one point, there a still image of Vin Diesel, whom Asia did not date but admitted that she fancied.

Peter Fonda wouldn't smack John Robinson in the face, so the hands smacking John actually belong to the Cinematographer Eric Alan Edwards.

Before Sarah's strip scene, she is outside the club with two other women. One of the women is Cole and Dylan Sprouse's mother.

Actor Jimmy Bennett claims his costar Asia Argento groomed him during the making of this film before eventually raping him when he was only 17 years old, one year younger than the age of consent in California where the assault allegedly took place.

Some of the Region 1 DVD copies of the film contain an error where the meth explosion scene appears to be missing. This is due to an authoring error during mass production.

The film stars three Oscar Nominees; Peter Fonda, Jeremy Renner and Winona Ryder.

The title comes from a biblical verse in Jeremiah 17:9, "The heart is deceitful above all things and beyond cure. Who can understand it?"

Girl Boy Girl is the story of Savannah Knoop's transformation to and from JT Leroy.