• Ported onto the PS2, in addition to a reduction in lighting and detail, the polygon count was toned down. Also, all of the cutscenes in the PS2 version are FMVs (meaning, they are pre-rendered and therefore don't take into account any recent changes made to the characters or areas, such as costume changes, blown up barrels and doors with bullet holes). On the plus side, there's an extra mini game called "Separate Ways", which is a five-chapter storyline that follows Ada's actions during the main game and also addresses some unanswered questions such as what happened to Leon's jacket and how Ashley met Ada.
  • The PlayStation 2 version has two extra costumes, a gangster outfit for Leon and a suit of armor for Ashley. While wearing the armor, Ashley is invincible, whereas Leon's gangster outfit only changes the way he shoots the Chicago Typewriter gun. Also, in the PlayStation 2 version a laser gun is available for use.
  • The Wii version includes all extras and costumes from previous editions, and improved graphics/properly rendered cutscenes over the PS2 version.
  • Unlike previous installments of Resident Evil games, the Japanese version is actually censored for violence this time. Compared to the American release, the Japanese version edits out some of the the more gruesome death animations like decapitations and exploding heads.