Elisha Cuthbert got stuck repeatedly in the melting wax bed while filming the final scenes of the movie. The "wax" was actually peanut butter.
In the church where Carly hides, as well as the movie theatre where Carly and Nick are hiding, most of the wax figures were actually extras wearing masks.
Jared Padalecki and Paris Hilton later appear in an episode of Supernatural (2005) together also centered around a Wax Museum. There's even reference to this movie in the episode.
While filming the abandoned sugar mill chase, Paris Hilton was embarrassed by her scream, so the first three times she screamed she had the whole cast and crew scream along with her.
Aside from the title and the setting of a wax museum, this film has no connection to the original film House of Wax (1953) in terms of plot.
Jared Padalecki is one foot taller than co-star Elisha Cuthbert. To make herself appear taller in scenes where she and Padalecki would be filmed together, Cuthbert taped two-inch blocks of wood to the bottoms of her boots. This was only done during scenes where they would be shot from the knee and up.
On 26 June 2004, a sound stage being used for the film burned to the ground during a test of special-effects equipment. The fire, started by a candle, destroyed a studio at Warner Bros Movie World on Australia's Gold Coast. One crew member was treated for burns to his arm, but no one else was injured. The smoke reached a nearby highway, which was not shut down.
Names mentioned in the script but not the film are the roadkill collector (Lester), and Carly and Nick's last name (Jones). Chad Michael Murray (Nick), in a radio interview, was shocked to hear his character finally had a last name, and said that it was an ongoing debate on set.
The town of Ambrose was constructed in 10 weeks, and was modeled after a real town in Eritrea called Asmara. Asmara was built by the Italians in Africa during World War II in the Modern Style rather than the Deco Style, which was more popular at the time.
Before Paris Hilton was cast as Paige Edwards, Jennifer Connelly and Kate Winslet were originally considered for the role. Her "That's hot" catchphrase is spoken by several characters, for this reason.
Jared Padalecki and Chad Michael Murray both starred in Gilmore Girls (2000) together.
This film and Tourist Trap (1979) share similar plot points despite this film being a remake of 1953's House of Wax (1953).
Brian Van Holt's next film (seven years after this one) was Bullet to the Head (2012).
Viewers have stated that Chad Michael Murray should've portrayed Wade instead, due to him having a lot of chemistry with Elisha Cuthbert, who portrays his character's sister. This notion was due to some stating that Nick and Carly's sibling relationship seemed subtly incestuous at times, even though that's not the case.
Though the film takes place in Florida, USA, the film was actually shot in Australia.
Jared Padalecki's first horror feature before ultimately starring in the long-running TV series, Supernatural (2005).
This film is the first horror remake that Jared Padalecki stars in. The second horror remake he starred in is Friday the 13th (2009).