Meat Loaf made a cameo appearance in 2009. Later on in the season, a "Dr. Paulson" was introduced for one episode (season five, episode twenty, "Simple Explanation"). A possible nod to Meat Loaf's character in Fight Club (1999), Robert Paulson.
Dr. Lisa Cuddy:
You need a lawyer.
With, very, very few exceptions, characters in the series don't wear eye protection when performing surgery. It is standard practice throughout hospitals in the United States to do so. However, this was a deliberate decision made by the director for theatrical reasons.
The Heel & Toe logo features a toy dancing couple on stage being stomped by a human's foot
The song used for the intro sequence is Massive Attack's "Teardrop". However, in many European countries an original piece of music by Scott Donaldson and Richard Nolan was used due to rights issues. From the second season onwards a new intro composed by Jason Derlatka and John Ehrlich was used.