The show was inspired by The Diagnosis Column in the New York Times Magazine which spotlights unusual medical cases. Executive producer Paul Attanasio came up with the concept and pitched it to the networks as a medical procedural. Creator David Shore revised the idea into a character drama where the medical cases became the instrument instead of the focus of the storytelling.
Dr. Gregory House:
We're missing something.
In some episodes, doctors are seen restraining a patient during a seizure. Patients having a seizure should never be restrained, as doing so can cause more harm.
The Heel & Toe logo features a toy dancing couple on stage being stomped by a human's foot
The song used for the intro sequence is Massive Attack's "Teardrop". However, in many European countries an original piece of music by Scott Donaldson and Richard Nolan was used due to rights issues. From the second season onwards a new intro composed by Jason Derlatka and John Ehrlich was used.