Hugh Laurie's own father was a doctor, and he feels a twinge of guilt at "being paid more to become a fake version of my own father."

According to David Shore, after Hugh Laurie's audition, executive producer Bryan Singer said, "See, this is what I want; an American guy." Singer was completely unaware of the fact that Hugh Laurie is English.

In several episodes, House is shown at home and his apartment number is 221B, a tribute to Sherlock Holmes famous London address, 221B Baker Street.

When emergency room doctors admit patients who have a known history of drug use or addiction, it is often notated in their patient charts using the acronym "H.O.USE" for "History of Use".

Hugh Laurie was reportedly earning $50,000 per episode in season one, which dramatically increased to $700,000 per episode in season eight.

Though other characters occasionally insinuate that Dr. Robert Chase (Jesse Spencer) was a bit dim, he actually came up with more correct diagnoses than any other supporting character over the course of the series.

On Inside the Actors Studio (1994), Hugh Laurie admitted that when he first read the script for this show (which did not have the title of "House M.D." at the time) he believed that the character of Wilson was the lead. He couldn't believe that a man such as House could be the star of the show.

Dr. House is a polyglot. He knows English, Spanish, Portuguese, Russian, French, Hindi (a little), and Mandarin.

Dr. Robert Chase (Jesse Spencer) is an intensivist, a doctor who specializes in intensive care. This specialty is new and uncommon in the United States, but well-established in Australia, where the character is from.

Hugh Laurie auditioned for the part of Dr. House via video shot in a hotel bathroom in Namibia, where he was shooting Flight of the Phoenix (2004). "It was the only place with enough light", Laurie claimed.

Hugh Laurie holds the world record for being the "most watched leading man on television" for playing Gregory House.

Robert Sean Leonard was the first actor to be cast.

Jesse Spencer and Jennifer Morrison became engaged in December of 2006. This was at roughly the time they were shooting the first episodes in which their characters, Dr. Robert Chase and Dr. Allison Cameron, began a romantic relationship.

One of the movie posters on Dr. James Wilson's (Robert Sean Leonard's) office is Orson Welles' Touch of Evil (1958), where Orson Welles played a detective with a gimp leg, who solves crimes purely on his intuition. Clearly one of the influences for the character of Dr. Gregory House (Hugh Laurie).

The tagline "Humanity Is Overrated" was used in Finland. In November 2007, Pekka-Eric Auvinen shot eight people to death in a Finnish school and used the same phrase, after which the phrase was removed from the show's website.

Lisa Edelstein left the show after shooting the season seven finale. According to series creator David Shore, if Edelstein would have told them that she wasn't coming back, he wouldn't have ended the season like he did, and would have written the character out as she deserved it.

Although the Diagnostic Medicine team deal with all types of diseases, Dr. Gregory House (Hugh Laurie) and his colleagues hold titles in various subspecialties: Dr. Eric Foreman (Omar Epps) is a neurologist; Dr. Allison Cameron (Jennifer Morrison) is an immunologist/allergist; Dr. Robert Chase (Jesse Spencer) is an intensivist; Dr. Chris Taub (Peter Jacobson) is a plastic surgeon; Dr. Lawrence Kutner (Kal Penn) specialized in sports medicine; Dr. Remy "Thirteen" Hadley (Olivia Wilde) is an internist. As for Dr. House, he is double-certified in infectious disease and nephrology (as mentioned in season one, episode three, "Occam's Razor").

For the first season, FOX insisted that House must have some kind of enemy or someone telling him he couldn't behave like that. Series creator David Shore was hesitant about the idea, but ended up creating Edward Vogler (Chi McBride), but stating from the beginning that he was only going to be in five episodes, and then he would leave the show.

Lupus is the most common red herring diagnosis. After this was pointed out, it became a running joke on the show.

House makes the comment, "Haven't you ever seen Dead Poets Society?" Robert Sean Leonard played Neil Perry in Dead Poets Society (1989).

When a student in the audience of Hugh Laurie's edition of Inside the Actors Studio (1994) asked Laurie if he thought Dr. House should be romantically involved with Dr. Allison Cameron, Dr. Lisa Cuddy, or Dr. James Wilson, Laurie said, "I suspect that if the show runs long enough, he's going to run through all of them. What order that unfolds in is not for me to say. I think any of those relationships is, of course, believable. Two people can always find some comfort or attraction, so I think all are possible. I think Robert (Robert Sean Leonard, who plays Dr. Wilson) might have something to say about it. I don't know how Robert would take that. But you know, I'm game."

The aerial shots of the hospital are actually of the back of Frist Student Center at Princeton University.

Hugh Laurie (Dr. Gregory House) is the only actor to appear in all 178 episodes of the series.

Dr. Eric Foreman (Omar Epps) never wears the same outfit twice.

The production company credit at the end of the show for Bad Hat Harry Productions (executive producer Bryan Singer's company) ("That's some bad hat, Harry") is a reference to Jaws (1975).

After receiving his honorary doctorate in fine arts, television satirist Stephen Colbert placed several pictures of other famous television doctors who inspired him on the mantle-piece of his show's set. One of these is of Hugh Laurie as Dr. Gregory House. The others are Bill Cosby as Dr. Cliff Huxtable and Noah Drake from General Hospital (1963). As a response, the creators of this show placed a picture of Colbert on the desk of Gregory House in the show's fifth season that can be seen from time to time. Due to Laurie's show winning an Emmy over Colbert's, and because Laurie received an OBE (Officer of the Most Excellent Order of the British Empire) while Colbert did not (nor could he, since he's not British), Colbert named House to his enemies list.

Dr. Robert Chase was originally written as a British man. Shortly before production began, the decision was made to change him to an American. Though he's capable of performing an American accent (and does in a couple of episodes of the show), Jesse Spencer, who is Australian, successfully lobbied for the character to be made Australian instead. He wanted it because scripts had to be changed anyway, and he felt that American television had rarely seen a non-stereotypical Australian character.

The show was inspired by The Diagnosis Column in the New York Times Magazine which spotlights unusual medical cases. Executive producer Paul Attanasio came up with the concept and pitched it to the networks as a medical procedural. Creator David Shore revised the idea into a character drama where the medical cases became the instrument instead of the focus of the storytelling.

Dr. Gregory House's (Hugh Laurie's) most famous line "Everybody lies" was used by another doctor about a year and a half before the pilot episode, in another medical show, the sitcom Scrubs (2001). Dr. Bob Kelso (Ken Jenkins) says "Everybody lies, Dr. Turk" in season two, episode twelve, "My New Old Friend", after Dr. Chris Turk (Donald Faison) failed to prevent an old lady from driving home because she said she was fine enough to drive and that she had to pick up her grandkids.

One of the promotional posters featured Hugh Laurie wrapped in two snakes with a pair of wings behind him, a re-creation of the Greek Caduceus symbol. Foreign fans might be confused by this, because the correct symbol is the rod of Asclepius, the healer, a similar symbol having only one coiled snake and no wings. However, within the U.S., the Caduceus is as commonly used as the more correct Rod of Asclepius, as its use was popularized around the turn of the century. As the Caduceus is actually the symbol associated with the Greek god Hermes, and therefore a symbol of Wisdom, its use has long been a point of controversy and satirical humor within the U.S. medical community.

Hugh Laurie did not actually like the title "House".

Numerous times throughout the series, House mentions watching The O.C. (2003). In season four, Olivia Wilde joined the cast as a series regular. She also played a recurring part during season two of The O.C. (2003). She played a bisexual in both series.

In his book "Hamilton: The Revolution," Lin-Manuel Miranda says that the inspiration for the "Hamilton" song "You'll Be Back" came from his friendship with Hugh Laurie, which in turn came from his time as an actor on "House": "I was having a drink with Hugh Laurie, with whom I'd worked on his series House, and I told him I wanted to write a big breakup letter from King George to the colonies. Without blinking, he improved at me, 'Awwww, you'll be back,' wagging his finger. I laughed and filed it away. Thanks, Hugh Laurie. "

The standard way to use a cane is to hold it on the opposite side of the injured leg. Dr. House of course knows this, but, consistent with his contrary nature, insists on holding his cane on the same side as his injured leg.

It is common throughout the series for House and his team to suggest a diagnosis for a patient that was the previous episode's correct diagnosis.

Denis Leary, David Cross, Rob Morrow, and Patrick Dempsey were considered for the part of Dr. House.

Sándor Szakácsi, the Hungarian voice of Dr. House, died in March 2007. Consequently, he could only finish the dubbing of eleven episodes of the second season. As a tribute to him, the television channel decided to use the unfinished work, therefore in the first half of season two, episode twelve, "Distractions", they still heard Sándor, then the new voice, János Kulka took over the job. The commercial break (there is only one in Hungary) was inserted where the change took place, in the middle of a scene.

Kyle MacLachlan auditioned for the role of Dr. House. He described it as one of the worst auditions of his life.

In Dead Poets Society (1989), Robert Sean Leonard played a character under pressure from his father to become a doctor, but whose passion was to become an actor.

In season two, episode twenty-four, "No Reason", when Dr. House was shot and hospitalized, his hospital wristband was shown which revealed his date of birth as June 11, 1959, which is the same birth date as Hugh Laurie.

Three out of six original cast members are left-handed: Lisa Edelstein (Dr. Lisa Cuddy), Omar Epps (Dr. Eric Foreman), and Robert Sean Leonard (Dr. James Wilson).

The recurring character of Lucas Douglas was created to establish a spin-off series starring Michael Weston, but the producers decided not to make the series.

From a promo picture for the show's fourth season, it was discovered that Dr. James Wilson received his undergraduate degree from McGill University in Montreal, Québec. He'd been seen previously wearing a McGill sweater. He also received a degree from Columbia University's "School of Oncology".

The age of sexual consent in New Jersey, where the show was based, is sixteen. This premise would have changed several episodes. Given that the show is usually very aware of laws (as House and his team are often dealing with them), it must have been a creator's choice to stick with the idea of it being eighteen to keep as many viewers from complaining about a possible "underage" scenario. However, in season seven, episode ten, "Carrot or Stick", Dr. Robert Chase (Jesse Spencer) has a threesome at a wedding, and realizes that one of the women is seventeen. Upon realizing this, the girl reassures him having sex with her was not illegal.

In his office, Dr. James Wilson (Robert Sean Leonard) had posters from Robert Redford's Ordinary People (1980), Orson Welles' Touch of Evil (1958), and Sir Alfred Hitchcock's Vertigo (1958).

The motorcycle that Dr. House owned is a 2005 Honda CBR1000RR Repsol Replica.

This show took place in the Mercer County area of New Jersey. In the opening credits, there are shots of various locations around the area of Princeton, Trenton, West Windsor, and Plainsboro, including Princeton University. The hospital, Princeton-Plainsboro Teaching Hospital, was based on a real hospital in Princeton, Princeton Hospital, the University Medical Center at Princeton. An executive producer and the director of the pilot episode, Bryan Singer, is from the area, and attended West Windsor-Plainsboro High School.

The team performs an "LP" or Lumbar Puncture in nearly every episode.

Lisa Edelstein (Dr. Lisa Cuddy) and Peter Jacobson (Dr. Chris Taub) appeared in As Good as It Gets (1997) as the couple insulted by Jack Nicholson (Melvin Udall) for sitting at his table in the restaurant.

House is based on Sherlock Holmes, but Holmes, in turn, was based on a doctor Arthur Conan Doyle knew while studying medicine, a Dr. Bell, whose specialty was diagnosis.

The nickname "Thirteen" for Dr. Remy Hadley (Olivia Wilde) comes from the first few episodes of season four. House is trying to hire a new team from a possible thirty candidates. He assigns them numbers from one to thirty. Dr. Hadley has the number "Thirteen", which is considered unlucky by many. Despite the bad omen, she makes the team, but the name sticks.

Dr. House listens to jazz, plays the piano, and is fond of electric guitars. In real life, Hugh Laurie is an accomplished blues musician who plays several instruments.

Many of the actors and actresses have also been on the show Psych (2006). For example: Anne Dudek played Lucinda on Psych (2006) for the pilot episode. She also played Dr. Amber Volakis on this show for all of season four and part of season five. Jimmi Simpson played Mary on Psych (2006) in season three, episode sixteen, "An Evening with Mr. Yang". He also played Daniel Bresson on this show in season five, episode fifteen, "Unfaithful". Michael Weston played Adam Hornstock on Psych (2006) on season one, episode twelve, "Cloudy with a Chance of Murder". He also played Lucas Douglas on this show for part of season five. Frank Whaley played Robert on Psych (2006) on season one, episode seven, "Who Ya Gonna Call?" He also played Mr. X on this show on season four, episode five, "Mirror Mirror". Kurtwood Smith played Brett Connors on Psych (2006) on season one, episode ten, "Forget Me Not". He also played Dr. Obyedkov on this show on season three, episode fifteen, "Half-Wit". Scott Michael Campbell played Wes Hildenbach on Psych (2006) on season one, episode six, "9 Lives". He also played Joe Luria on this show on season two, episode twenty, "Euphoria: Part 1" and season two, episode twenty-one "Euphoria: Part 2". Mackenzie Astin played Jason Cunningham on Psych (2006) on season three, episode fifteen, "Tuesday the 17th". He also played Alan Alston on this show on season two, episode seventeen, "All In". Franka Potente played Nadia on Psych (2006) on season five, episode nine, "One, Maybe Two, Ways Out". She also played Lydia on this show on season six, episode one, "Broken, Part 1" and season six, episode two, "Broken, Part 2".

Several episodes were shot on-location at 4Play Gentleman's Club in Los Angeles, California.

Meat Loaf made a cameo appearance in 2009. Later on in the season, a "Dr. Paulson" was introduced for one episode (season five, episode twenty, "Simple Explanation"). A possible nod to Meat Loaf's character in Fight Club (1999), Robert Paulson.

Dr. Eric Foreman (Omar Epps) shares a name with the lead character on FOX's That '70s Show (1998), played by Topher Grace. However, Grace's character was named "Forman", and the similar names are purely coincidental.

Jesse Spencer, who plays Dr. Robert Chase, is one of few members in his family not in the medical profession. His father is a radiologist and his older brothers are an oculoplastic surgeon and an orthopedic surgeon. His younger sister is an anaesthetist.

Several main actors and actresses from Prison Break (2005) guest starred on this show, namely: Wentworth Miller, Dominic Purcell, Sarah Wayne Callies, and Robin Tunney.

This is the second long running medical drama that featured Omar Epps. The first was a stint as Dr. Dennis Gant in season three of ER (1994).

Jaundice/abdominal pain due to liver failure is an extremely common symptom of the final diagnosis, occurring in virtually all episodes. This is potentially another running gag like Lupus as a suggestion of diagnosis.

This was not the only time Peter Jacobson (Dr. Chris Taub) appeared on a medical show. He also played a patient on Scrubs (2006) named Mr. Foster, who died due to the doctors' negligence.

This show's tagline and series premise "Everybody lies" was first used on Scrubs (2001) season two, episode twelve, "My New Old Friend", when Dr. Robert Kelso (Ken Jenkins) explains to Dr. Christopher Turk (Donald Faison) that everybody lies during a series of bizarre patient complaints and accidents.

Early in the series (season one) Wilson's office is not where it is in later seasons. This is plainly visible in season one, episode four, "Maternity", when House is trying to avoid the "idiot" who "didn't know how to use birth control" by walking to the elevator. Where Wilson's door to his office comes to reside later on in the series, you see the entrance to the "McCormick Wing" (which also appears to be the pediatric wing). This is also problematic as you see rather early on in the show (but later on than this episode) that House and Wilson's balconies (ergo their offices) are across from one another.

Series creator David Shore has said that the character of House was inspired by the fictional character Sherlock Holmes, particularly with regard to drug use and his desire (and capacity) to solve the unsolvable. House uses Holmesian deductive techniques to diagnose his patients' problems. References to the sleuth range from the obvious (House's apartment number being 221B) to the subtle (his friendship with Dr. James Wilson and the similarities between the names House and Holmes, and Wilson and Watson). In the pilot episode, the patient's last name was Adler, and in the last episode of season two, the last name of the man who shot House was Moriarty. House's act of faking cancer in season three, episode fifteen, "Half-Wit", is similar to the Holmes story, "The Adventure of the Dying Detective" in which Holmes fakes a deadly eastern disease to catch a criminal. The character of Holmes, was in turn, based on a Doctor that Sir Arthur Conan Doyle knew while studying medicine, Dr. Joseph Bell, whose specialty was diagnosis. The reference is pushed further when, in season five, episode eleven, "Joy to the World", Wilson presents House with Joseph Bell's Manual of the Operations of Surgery as a Christmas gift. When House's staff begins to wonder why he would throw away the expensive gift, an amused Wilson begins making up a story about House having a closeted infatuation with a patient named Irene Adler, who he will always consider to be "the one who got away". Irene Adler is a prominent character in one Sherlock Holmes story who has been wrongly characterized as Sherlock Holmes' love interest in several adaptations. Here, the one who got away is a parallel to the fact that she was the one woman who defeated Sherlock Holmes, making Sherlock Holmes respect her. But he was never in love with her. The false story of Wilson about Irene Adler pays tribute to both of these facts. Also for a long while, House believed that his biological father was a friend of family named as Thomas Bell. See the following list of crime solvers who are also based on the character of Sherlock Holmes: Dr. Gil Grissom and D.B. Russell from CSI: Crime Scene Investigation (2000). Detective Robert Goren from Law & Order: Criminal Intent (2001). Adrian Monk from Monk (2002). Shawn Spencer from Psych (2006). Patrick Jane from The Mentalist (2008).

In September 2009, the British tabloid The Daily Express reported that Hugh Laurie was starting to suffer physical injury from years of walking with his character's pronounced limp.

The character of Dr. Allison Cameron was written out mainly because series creator David Shore wanted to show that not every character around Dr. Gregory House was going to end up being "corrupt". Shore has said it was really hard to let go of Jennifer Morrison, but the story was more important.

In April 2009, Kal Penn told Entertainment Weekly Magazine that the writers killed off his character on this show because he had asked to be allowed to leave the show to go work for the President Barack Obama Administration as the Associate Director in the White House Office of Public Liaison.