Hugh Laurie's own father was a doctor, and he feels a twinge of guilt at "being paid more to become a fake version of my own father."

During Hugh Laurie's audition, producer David Shore told how Bryan Singer, one of the executive producers, said, "See, this is what I want; an American guy." Singer was completely unaware of the fact that Hugh Laurie is British.

In several episodes, House is shown at home and his apartment number is 221B, a tribute to Sherlock Holmes famous London address, 221B Baker Street.

When ER doctors admit patients who have a known history of drug use or addiction, it is often notated in their patient charts using the acronym HOUSE for History of Use.

Hugh Laurie was reportedly earning $50,000 per episode in season one, which dramatically increased to $700,000 per episode in season eight.

Though other characters occasionally insinuate that Dr. Chase is a bit dim, he actually comes up with more correct diagnoses than any other supporting character over the course of the series.

On Inside the Actors Studio (1994), Hugh Laurie admitted that when he first read the script for House (which did not have the title of "House M.D." at the time) he believed that the character of Wilson was the lead. He just couldn't believe that a man such as House could be the star of the show.

Dr. Gregory House was based on Sherlock Holmes... but Holmes, in turn, was based on a Doctor that Sir Arthur Conan Doyle knew while studying medicine, Dr. Joseph Bell, whose specialty was diagnosis. The reference is pushed further when, In episode 11 of the fifth season, Wilson presents House with Joseph Bell's Manual Of the Operations of Surgery as a Christmas gift. When House's staff begin to wonder why he would throw away the expensive gift, an amused Wilson begins making up a story about House having a closeted infatuation with a patient named Irene Adler whom he will always consider to be "the one who got away". Irene Adler is a prominent character in one Sherlock Holmes story who has been wrongly characterised as Sherlock Holmes' love interest in several adaptations. Here the one who got away is a parallel to the fact that she was the one woman who defeated Sherlock Holmes, making Sherlock Holmes respect her. But he was never in love with her. The false story of Wilson about Irene Adler pays tribute to both of these facts. Also for a long while House believes that his biological father is a friend of family named as Thomas Bell.

Dr. House is a polyglot. He knows English, Spanish, Portuguese, Russian, French, Hindi (a little), and Mandarin.

Hugh Laurie holds the world record for being the "most watched leading man on television" for playing Gregory House.

In September 2009, the British tabloid The Daily Express reported that Hugh Laurie was starting to suffer physical injury from years of walking with his character's pronounced limp.

Hugh Laurie auditioned for the part of Dr. House via video shot in a hotel bathroom in Namibia, where he was shooting Flight of the Phoenix (2004). "It was the only place with enough light," the actor claimed.

Robert Sean Leonard was the first actor to be cast.

Dr. Robert Chase (Jesse Spencer) is an intensivist, a doctor who specializes in intensive care. This specialty is new and uncommon in the United States, but well-established in Australia, where the character is from.

One of the movie posters on Wilson's office is Orson Welles' Touch of Evil (1958), where Orson Welles plays a detective with a gimp leg, who solves crimes purely on his intuition. Clearly one of the influences for the character of Dr. House.

Although the Diagnostic Medicine team deal with all types of diseases, House and his colleagues hold titles in various subspecialties: Dr. Foreman is a neurologist; Dr. Cameron is an immunologist/allergist; Dr. Chase is an intensivist; Dr. Taub is a plastic surgeon; Dr. Kutner specializes in sports medicine; Dr. Hadley (Thirteen) is an internist. As for Dr. House, he is double-certified in infectious disease and nephrology (as mentioned in episode #1.3).

The tagline "Humanity Is Overrated" was used in Finland. In November 2007 Pekka-Eric Auvinen shot eight people to death in a Finnish school and used the same phrase, after which the phrase was removed from the show's website.

In the season 2 episode "Clueless", Wilson is scrolling through the TV shows House has recorded. One show listed is "The OC", which House had mentioned previously that he watches. Another show listed is Blackadder, a British comedy starring Rowan Atkinson, which is one of Hugh Laurie's (House) most famous roles.

For the first season, Fox insisted that House must have some kind of enemy or someone telling him he couldn't behave like that. David Shore was hesitant about the idea, but ended up creating Chi McBride's character, Edward Vogler, but stating from the beginning that he was only going to be in five episodes, and then he would leave the show.

The aerial shots of the hospital are actually of the back of Frist Student Center at Princeton University.

Foreman never wears the same outfit twice.

Hugh Laurie (Dr. Gregory House) is the only actor to appear in all 178 episodes of the series.

House makes the comment, "Haven't you ever seen Dead Poets Society?" Actor Robert Sean Leonard plays Neil Perry in Dead Poets Society.

After receiving his honorary doctorate in fine arts, TV satirist Stephen Colbert placed several pictures of other famous TV doctors who inspired him on the mantle-piece of his show's set. One of these is of Hugh Laurie as Dr. Gregory House. The others are Bill Cosby as Dr. Cliff Huxtable and Noah Drake from General Hospital. As a response, the creators of House placed a picture of Colbert on the desk of Gregory House in the show's 5th season, that can be seen from time to time. Due to both Laurie's show winning an Emmy over Colbert's, and because Laurie received an OBE (Officer of the Most Excellent Order of the British Empire) while Colbert did not (nor could he, since he's not British), Colbert named House to his enemies list.

The Production Company credit at the end of the show for Bad Hat Harry productions ("That's some bad hat, Harry") is a reference to the movie Jaws (1975).

Lupus is the most common red herring diagnosis. After this was pointed out, it became a running joke on the show.

The show was inspired by The Diagnosis Column in the New York Times Magazine which spotlights unusual medical cases. Executive Producer Paul Attanasio came up with the concept and pitched it to the networks as a medical procedural. Creator David Shore revised the idea into a character drama where the medical cases became the instrument instead of the focus of the storytelling.

Dr. House's most famous line "Everybody Lies" was in fact used by another doctor about a year and a half before the pilot episode, in another medical show, the sitcom Scrubs (2001). Dr. Bob Kelso says "Everybody lies, Dr. Turk" in the season 2 episode Scrubs: My New Old Friend (2003), after Dr. Turk fails to prevent an old lady from driving home because she said she was fine enough to drive and that she had to pick up her grandkids.

Numerous times throughout the series, House mentions watching The O.C. (2003). In season four Olivia Wilde joins the cast as a series regular. She also played a recurring part during season two of The O.C. (2003). She played a bisexual in both series.

The standard way to use a cane is to hold it on the opposite side of the injured leg. Dr. House of course knows this, but, consistent with his contrary nature, insists on holding his cane on the same side as his injured leg.

One of the promotional posters features Hugh Laurie wrapped in two snakes with a pair of wings behind him, a recreation of the Greek Caduceus symbol. Foreign fans might be confused by this, because the correct symbol is the rod of Asclepius, the healer, a similar symbol having only one coiled snake and no wings. However, within the US, the Caduceus is as commonly used as the more correct Rod of Asclepius, as its use was popularized around the turn of the century. As the Caduceus is actually the symbol associated with the Greek god Hermes, and therefore a symbol of Wisdom, its use has long been a point of controversy and satirical humor within the US medical community.

Hugh Laurie did not actually like the title "House".

In the season 2 episode "Informed Consent," House says, "Pay no attention to the man behind the curtain." The patient, Ezra Powell, was played by Broadway legend Joel Grey, who debuted as the Wizard of Oz in the Tony award winning musical, Wicked.

Sándor Szakácsi, the Hungarian voice of Dr. House, died in March 2007. Consequently, he could only finish the dubbing of 11 episodes of the second season. As a tribute to him, the TV channel decided to use the unfinished work, therefore in the first half of episode 12 of season 2 we still hear Sándor, then the new voice, János Kulka takes over the job. The commercial break (there is only one in Hungary) is inserted where the change takes place - actually in the middle of a scene.

In Dead Poets Society (1989), Robert Sean Leonard played a character under pressure from his father to become a doctor, but whose passion was to become an actor.

Denis Leary, David Cross, Rob Morrow, and Patrick Dempsey were considered for the part of Dr. House.

The recurring character of Lucas Douglas was created to establish a spin-off series starring Michael Weston, but the producers decided not to make the series.

Three out of six original cast members are left-handed: Cuddy, Foreman and Wilson.

Kyle MacLachlan auditioned for the role of Dr. House. He described it as one of the worst auditions of his life.

Dr Chase was originally written as a British man. Shortly before production began, the decision was made to change him to an American. Though he's capable of performing an American accent (and does in a couple of episodes of the show), Jesse Spencer, who is Australian, successfully lobbied for the character to be made Australian instead. He wanted it because scripts had to be changed anyway and he felt that American TV had rarely seen a non-stereotypical Australian character.

The show takes place in the Mercer County area of New Jersey. In the opening credits, there are shots of various locations around the area of Princeton, Trenton, West Windsor, and Plainsboro, including Princeton University. The hospital, Princeton-Plainsboro Teaching Hospital, is based on a real hospital in Princeton, Princeton Hospital, the University Medical Center at Princeton. An Executive Producer and the director of the pilot episode, Bryan Singer, is from the area, and attended West Windsor-Plainsboro High School.

From a promo picture for the show's fourth season, it was discovered that Dr. Wilson received his undergraduate degree from McGill University in Montreal, QC. He'd been seen previously wearing a McGill sweater. He also received a degree from Columbia University's "School of Oncology" [sic].

In his office, Dr. Wilson (Robert Sean Leonard) has posters from movie Robert Redford's Ordinary People (1980) and the classic films Orson Welles's Touch of Evil (1958) and Alfred Hitchcock's Vertigo (1958).

Patrick Stump, singer of Fall Out Boy, is in episode 17 of season 8. He plays Micah.

The motorcycle that Dr. House owns is a 2005 Honda CBR1000RR Repsol Replica.

The Team performs an LP or Lumbar Puncture in nearly every episode.

Lisa Edelstein and Peter Jacobson both played in the movie As Good as It Gets (1997) starring Helen Hunt and Jack Nicholson at the same scene, sitting next to each other, years before the show even premiered.

Many of the actors that have been featured on House M.D. have also been on the show "Psych" (2006). For example: Anne Dudek played Lucinda on Psych for the "Pilot". She also played Dr. Amber Volakis on House for all of season 4 and part of season 5. Jimmi Simpson played Mary on Psych for "An Evening with Mr. Yang". He also played Daniel Bresson on House for "Unfaithful". Michael Weston played Adam Hornstock on Psych for "Cloudy...Chance of Murder". He also played Lucas Douglas on House for part of season 5. Frank Whaley played Robert on Psych for "Who You Gonna Call". He also played Mr. X on House for "Mirror Mirror". Kurtwood Smith played Brett Connors on Psych for "Forget Me Not". He also played Dr. Obyedkov on House for "Half-Wit". Scott Michael Campbell played Wes Hildenbach on Psych for "9 Lives". He also played Joe Luria on House for both "Euphoria: Part 1" and "Euphoria: Part 2". Mackenzie Astin played Jason Cunningham on Psych for "Tuesday the 17th". He also played Alan Alston on House for "All In". Franka Potente played Nadia on Psych for "One, Maybe Two, Ways Out". She also played Lydia on House for "Broken".

Dr.House listens to jazz, plays the piano, and is fond of electric guitars.

Omar Epps' character, Eric Foreman, shares a name with the lead character on FOX's That '70s Show (1998), played by Topher Grace. However, Grace's character is named Forman and the similar names are purely coincidental.

Several episodes were shot on location at 4Play Gentleman's Club in Los Angeles, CA.

Meat Loaf made a cameo appearance in 2009. Later on in the season a "Dr. Paulson" is introduded for a single episode(Simple Explanation- Season 5 Episode 20). A potential nod to Meat Loaf's character in Fight Club, Robert Paulson.

Several main actors from Prison Break (2005) (another drama series airing at the same time) guest starred on House, namely: Wentworth Miller, Dominic Purcell, Sarah Wayne Callies, and Robin Tunney.

This is the second long time running medical drama to star Omar Epps. The first was a stint as Dr. Dennis Gant in season 3 of E.R.

House was actually not the only time Peter Jacobson (Dr. Chris Taub) appeared on a medical show. He also played a patient in Scrubs (2006) named Mr. Foster, who passed away due to the doctors' negligence.

House M.D.'s tagline and series premise "Everybody Lies" was first used on Scrubs, S2: E12, when Dr. Kelso explains to Turk that everybody lies during a series of bizarre patient complaints and accidents.

Jesse Spencer and Jennifer Morrison became engaged in December of 2006. This was at roughly the time they were shooting the first episodes in which their characters, Dr. Chase and Dr. Cameron, began a romantic relationship.

The character of Cameron was written out mainly because David Shore wanted to show that not every character around House was going to ended up being 'corrupt'. Shore has said it was really hard to let go of Jennifer Morrison, but the story was more important.

Lisa Edelstein left the show a while after shooting the season 7 finale. According to David Shore, if Edelstein would have told them that she wasn't coming back, he wouldn't have ended the season like he did and would write out the character as she deserved it.

David Shore has said that the character of House is inspired by the fictional character Sherlock Holmes, particularly with regard to drug use and his desire (and capacity) to solve the unsolvable. House uses Holmesian deductive techniques to diagnose his patient's problems. References to the sleuth range from the obvious (House's apartment number being 221B) to the subtle (his friendship with Dr. James Wilson and the similarities between the names House and Holmes, and Wilson and Watson). In the very first (pilot) episode the patient's last name is Adler, and in the last episode of season two, the last name of the man who shot House is Moriarty. House's act of faking cancer in "Half-Wit" (Episode 15 of Season 3) is similar to the Holmes story, "The Adventure of the Dying Detective" in which Holmes fakes a deadly eastern disease to catch a criminal.

When a student in the audience of Hugh Laurie's edition of Inside the Actors Studio (1994) asked Laurie if he thought Dr. House should be romantically involved with Cameron, Cuddy or Wilson, Laurie said, "I suspect that if the show runs long enough, he's going to run through all of them. What order that unfolds in is not for me to say. I think any of those relationships is, of course, believable. Two people can always find some comfort or attraction, so I think all are possible. I think Robert [Robert Sean Leonard, who plays Dr. Wilson] might have something to say about it . . . I don't know how Robert would take that. But you know, I'm game."

In April 2009, Kal Penn told Entertainment Weekly Magazine that the writers killed off his character on "House M.D." because he had asked to be allowed to leave the show to go work for the Barack Obama Administration as the Associate Director in the White House Office of Public Liaison.

In "Blowing the Whistle" (Season 8, Episode 15) House is playing Call of Duty with Taub and House's gamer tag name is Occams Chainsaw. It's a play on Occam's razor theory which says "Among competing hypotheses, the one with the fewest assumptions should be selected", thus showing House's doctoral personality being based on the Occam's razor theory.

The Age of Sexual Consent in New Jersey where the show is based is 16. This premise would have changed a number of episodes. Given that the show is usually very aware of laws (as House and his team are often dealing with them), it must have been a directorial choice to stick with the common misconception of it being 18 nationwide. However in season 7 episode 10, Dr. Chase has a threesome at a wedding and realizes one of the woman is actually 17. Upon realizing this, the girl reassures him having sex with her was not illegal.

The nickname "Thirteen" for Olivia Wilde's character Dr. Remy Hadley comes from the first few episodes of Season 4. House is trying to hire a new team from a possible 30 candidates. He assigns them numbers from 1 to 30. Dr. Hadley has the number '13' which is considered unlucky by many. Despite the bad omen she makes the team but the name sticks.