Frankie wears a stylized Powerpuff Girls shirt.

Wilt is named after the basketball player Wilt Chamberlain.

In Foster's Home for Imaginary Friends: Bloooo (2004), where Bloo becomes ill and turns white, Wilt, Eduardo, and Coco think of ways to capture the ghost while mentioning several movie titles pertaining to ghosts. (Coco says 'Co coco!' as the song 'Ghostbusters!' goes, and Wilt talks about the Star Wars: Episode I - The Phantom Menace (1999).)

This is the first Cartoon Network Studios show done in Macromedia Flash, enabling a small staff to produce an entire episode in-house.

There is a stuffed Eduardo doll in Terrence's room.

The character Mr. Herriman is loosely based on Peter Cushing's portrayal as Dr. Abner Perry in At the Earth's Core (1976).

The character Frankie is loosely based on show writer Lauren Faust.

There's a bumper sticker in Terrence's room that says "Here's the Beef".

Creator Craig McCracken got the idea for the show when he and the show's co-developer Lauren Faust adopted 2 chocolate lab dogs.

Bloo is the only character to appear in every episode.

The whereabouts of Mac's father is never mentioned and it is assumed that Mac's mother is raising Mac and Terrence as a single parent. The only slight reference to Mac's father is when Bloo narrates Mac's school by opening Macs scene with "A boy with no father..." But Mac quickly scorns him implying it to be a sensitive subject.

In the TV movie "House of Bloo's" (the pilot), an Eduardo doll can be seen in the back of Terrence's room.

Tara Strong, Grey DeLisle, Tom Kenny and Jeff Bennett previously worked on Xiaolin Showdown.