Drake Bell's character is mostly based on Spider-Man. A few years after this movie he voiced Spider-Man in the TV series Ultimate Spider-Man (2012) and shares the same birthday as Tobey Maguire, the original Spider-Man.
Jeffrey Tambor filmed his role during a two-day break in the shooting of Hellboy II: The Golden Army (2008).
Michael Papajohn, who plays the mugger who ends up gunning Rick's parents down, originated the role of Carradine--the man who steals Uncle Ben's car after shooting him--in Spider-Man (2002).
Was originally called "Superhero!", because of the other David Zucker movies Airplane! (1980) and The Naked Gun: From the Files of Police Squad! (1988). It was changed to "Superhero Movie" because of the success of Date Movie (2006) and Epic Movie (2007).
Craig Bierko was cast as Wolverine, he appears in the poster and in the cast credits, but his scenes were cut. In the final cut, only Richard Tillman appears as Wolverine.
It's the second film with Leslie Nielsen and Robert Hays (who plays Blaine Riker, Rick's father). Previously, they played together in Airplane! (1980).
Producer David Zucker had previously worked with Robert Hays and Leslie Nielsen--Hays in Airplane! (1980) and Nielsen in "Airplane1" and The Naked Gun: From the Files of Police Squad! (1988).
According to the commentary, Rip Torn was to play the "Lunatic Editor" but for some reason, not disclosed, was replaced.
In the scene where Aunt Lucille is saying "Rick walked off a class trip" Uncle Albert is reading a newspaper. If you look closely the back page of the newspaper is an advertisement for a book called "Forgiving the Franklins" which is actually a movie (Forgiving the Franklins (2006)) written by Jay Floyd, who is a clearance administrator on this film.
Reuses some gags from the Naked Gun series, which was also produced by David Zucker. Like in The Naked Gun: From the Files of Police Squad! (1988), a person in a wheelchair receives an encouraging pat on the back by a character portrayed by Leslie Nielsen and subsequently falls off of a building. Like in The Naked Gun 2½: The Smell of Fear (1991), an esteemed personality gets mistaken for a bad guy and thus disrobed and humiliated on a stage by the main character.
Robert Hays plays Blaine Riker. In "Airplane!" (1980), he played a character named Ted Striker. Both of these films were produced by David Zucker.