Craig Ferguson's sidekick Geoff Peterson was created by MythBusters (2003) regular Grant Imahara after losing a wager to Ferguson that his Twitter followers couldn't get Imahara 100,000 twitter followers of his own

The opening theme is sung by Craig Ferguson himself.

CBS held auditions for the host job by letting their nominees host for one week, which 'Craig Ferguson' obviously won. The others who auditioned were Michael Ian Black, Damien Fahey and D.L. Hughley.

In the "Pick a Pic" opening, which says that it's time to play "Pick a Pic", there are 24 (twenty-four) briefly flashed pictures. These 24 pictures are on a loop which displays them three times throughout this opening.