(at around 3 mins) The photos of mutations that play during the opening credits are not of atomic mutation, but birth defects caused by the use of Agent Orange in Vietnam.

The gas station set was built on location in Morocco. It was so authentic that occasionally someone not involved in the production would stop to buy gas.

The mutants were created by CGI, physical effects or both. Most of the mutants with full deformations were created by prosthetic makeup. But the deformed children who were playing were digitally distorted using tracking dots on their faces. Ruby was a mixture of the two, using the tracking dots for distortion and prosthetic teeth.

Almost all of Ted Levine's actions and lines were improvised.

There was allegedly great difficulty shooting the scenes where a gun was pointed at the baby, not because the child was too scared, but because it kept trying to play with the gun.

Wes Craven and producer Peter Locke originally wanted to film the new version in the exact same desert location as the 1977 film but when they went out to scout the locations they found a number of condominium developments had been built.

Make-up artist Greg Nicotero was featured as Cyst, the mutant with the halo head-gear.

Temperatures soared in excess of 120 degrees Fahrenheit on the Moroccan desert set.

Ivana Turchetto, who played Big Mama, agreed to have her head shaved for $1000.

This movie and the original were inspired by the legend of Alexander "Sawney" Bean, the psychopathic head of a Scottish clan that reportedly killed 1,000 people to feed their inbred brood. Bean and company would set booby traps for travelers and then attack. Eventually, the disappearances drew the attention of King James VI, who put an end to Bean's reign and massacred his entire family. Although some say the whole thing never happened and was a smear campaign by the British, many still believe in the "Sawney" tale.

The making of featurette on the DVD indicates that at some point during production, the character of Papa Jupiter was going to have a parasitic twin jutting out of his chest. The effect was scrapped for the final film, leaving him the only one of the "mutants" without any apparent mutation.

The car crash scene, where the family's car and trailer are sabotaged, took 3 days to film.

The mutants have the following deformities: Big Brain= suffers from an extreme case of hydrocephalus and goitres, explaining his large distended head and bloated throat. Big Mama= lacks deformities entirely aside from her baldness and obesity. Cyst= suffer from neurofibromatosis, which explains the reddish lesions covering his body. Cyst is first seen by Doug Bukowski dragging a female corpse through the nuclear test village. Goggle= having two patchjob slits on his face in place of a nose, as well as patchy pink and red skin. . Lizard= a severe cleft lip and malformed jaw. Pluto= misshapen head and face and appears to be mentally impaired. Ruby= fingers are fused together, possibly from Syndactyly while the appearance of her face suggests Goldenhar syndrome. Venus and Mercury [two mutant children]= Like Ruby, Venus possibly has Goldenhar syndrome and Mercury has wide eyes and a skin disorder that causes his flesh to appear bluish.

About 2 minutes were cut to achieve the R rating.

The original film was threatened with an X rating, accordingly, this film was also threatened with a NC-17 rating.

The nuclear crater that Doug encounters is completely computer generated.

Alexandre Aja and art director Grégory Levasseur originally planned to film in Morocco because of its similarity to the New Mexico desert. Initially the producers objected to this, for fear of terrorist attacks, but after Aja and Levasseur failed to find suitable locations in the US, they relented.

Sand storms occurred on a daily basis throughout the shooting of this film in Morocco.

To get around the difficulties of shooting inside a tiny trailer, production designer Joseph C. Nemec III built a set of the inside of the trailer that was actually 30% bigger than the real thing.

Ranked third at the box office during its opening week.

The film is set in New Mexico and strongly implies that a large number of atmospheric nuclear weapon tests were performed in that state. In fact, the only atmospheric nuclear detonation in New Mexico was the Trinity test, the first test of a nuclear device conducted on July 16th 1945. The United States carried out most of its atmospheric nuclear weapons tests at the Nevada Test Site and in the Marshall Islands at the lagoons of Bikini and Eniwetok between 1946 and 1962.

Director Aja and art director Grégory Levasseur chose not to film in the original's filming location of Victorville, California, and instead scouted many locations for filming including Namibia, South Africa, New Mexico, and Mexico. The two settled on Ouarzazate in Morocco, which was also known as "the gateway to the Sahara Desert".

Papa Jupiter (Billy Drago) displays no deformities. However, as shown in The Making Of, Papa Jupiter has a large parasitic twin attached to his upper left torso. The young children of the film had their deformities added by CGI, with the exception of Ruby (Laura Oritz) who had a combination of CGI and makeup.

Wes Craven, who directed the original 1977 film, considered a remake after he saw the success of other horror remakes such as the Texas Chainsaw Massacre and The Amityville Horror. The search then began for filmmakers to helm the project. Marianne Maddalena, Craven's longtime producing partner, came across Alexandre Aja and his art director/collaborator Gregory Levasseur, who had previously made the French slasher film Haute Tension (2003). Upon showing the film to Craven and the rest of the producing crew, Craven commented that they "demonstrated a multi-faceted understanding of what is profoundly terrifying. After viewing the film and then meeting the filmmakers, I knew I wanted to work with them." Aja and Levasseur then began to rewrite the story in what is the pair's first American production.

K.N.B. Group Inc. spent over six months designing the mutants, first using 3D designer tools such a ZBrush, allowing them to use a computer to generate their sculptures. After the prosthetics were made, they could be fitted to the actors before filming. Robert Joy (Lizard) explained, "Every day, these amazing artists took more than three hours to transform me into something that could only be found in a nightmare."

Jamison Goei and his team, who had done previous work on Hellraiser Hellseeker (2002) and Halloween Resurrection (2002), had done over 130 visual effects for the film. A large part of that was digitally constructing the testing village, which in actuality was only one built street with others digitally added. The team also warped the mutants faces slightly, which is shown mostly in the character of Ruby.

Prior to filming, director Alexandre Aja and Gregory Levasseur had already conceived an idea for the mutants' appearance. Aja stated "We based all our descriptions and directions on real documents, pictures, and footage that we found on the effects of nuclear fallout in Chernobyl and Hiroshima"

The mini-series of The Ten Commandments (2006) was being filmed in Morocco nearby. The cast and crew of both productions were all staying at the same hotel.

In-between takes, the production crew would stage mock-fights with various prop weapons.

Over 16 different nationalities worked on the film, which was filmed in Morocco.

Nivek Ogre (Kevin 'ohGr' Ogilvie) of industrial/goth group Skinny Puppy auditioned for the role of Lizard but didn't get the role as he claims to have been way over the top and scared them. "I really like the remake of The Hills Have Eyes. I auditioned for that!" [Which part?] "Lizard. I was in all their faces, I went way over the top and they were scared of me, but they sent back really good feedback to the agency I was with at the time."

The mine shaft location was found in Morocco.

When casting for the mutants, associate producer Cody Zwieg explained: "We needed to find actors who could not only perform the stunt work, handle the extensive makeup and perform in that makeup, but who truly could embody the fierce, primal nature of the mutants way of life." To play the part of Pluto, Aja looked to Michael Bailey Smith, who had been in a Nightmare on Elm Street 5: The Dream Child (1989). They cast Robert Joy as Lizard, as he appeared in films such as Amityville 3-D (1983) and Land of the Dead (2005). Ezra Buzzington, impressed with the filmmakers, agreed to play the role of Goggle and even watched a documentary about human cultures engaging in cannibalism. To play the mutant leader, Billy Drago was cast. Drago had a similar role in Brian De Palma's The Untouchables (1987) and other horror features. The most difficult mutant to cast was Ruby, who was a "touch of sweetness to the madness of the mutants." Laura Ortiz was ultimately cast, making her film debut.

(at around 1h 18 mins) The TV show that Big Mama is watching is Divorce Court (1999) This film's producer, Peter Locke, also produced a show called Divorce Court (1984).

Originally rated NC-17 for strong gruesome violence, but was then edited down to an R-rating.

Bobby's handgun is a Beretta Cougar 8045.

The doom town as it was called wasn't in New Mexico but set up at the Nevada Test Site.

Big Bob's revolver is a Taurus Model 66.

The service station was called 'Gas Haven' which rhymes with Wes Craven.

This version runs approximately 15 minutes longer than the original.

The family dogs are named "Beauty" and "Beast". Emilie de Ravin plays the character "Belle" on Once Upon a Time (2011).

Vinessa Shaw (Lynn) and Aaron Stanford (Doug) go on to star together in the 2017 movie 'Clinical'. They play Dr. Jane Mathis and Miles respectively.

The unrated DVD version was released on June 20, 2006.

The R.V. is a 1988 Airstream International.

The shotgun used by the gas station attendant (Tom Bower), the mutant Cyst (Greg Nicotero), and finally Doug (Aaron Stanford) is High-standard model K-1200 riot deluxe model.

The SUV used to pull the RV is a 1990 Chevrolet Suburban Silverado [V-2500].

The car Big Bob tries to start at the gas station is a 1979 Oldsmobile Delta 88 Royale.

Remake of Wes Craven's 1977 film of the same name.

With the Aaron Stanford character, the filmmakers were looking for someone similar to Dustin Hoffman did in Straw Dogs (1971), where Hoffman was an ineffectual nerd who rises to heroism in the end and commits ghastly acts of violence. Stanford in the films also markedly physically resembles this films director, Alexandre Aja.

Body count: 17

Originally the trailer attack scene was supposed to be more gruesome. Alexandre Aja had the idea of replacing the birds with kittens and having the mutants put the kittens in a blender with milk and turn it on for the mutants to drink. He pitched the idea to Wes Craven who strongly disapproved and was fearful people would copycat the scene.