Thirteen episodes were produced but only nine were aired.

Hale's dog (as seen in "Who's Your Daddy") is Johnny Messner real-life bulldog, Buddha.

The title of this series is the reason why Microsoft unsuccessfully tried to renew the trademark of the fighting game franchise of the same name in 2012. However, in early 2013, Fox and Microsoft signed a Trademark Coexistence Agreement, which would allow both companies to use similar branding.

On an interview panel for Pushing Daisies (2007),in 2007, Chi McBride said, "I try to make choices based on material 'except for that one show I did called 'Killer Instinct' or as I called it, 'Kill It, It Stinks'.