J.P. Manoux stood in for David Spade as the voice of Kuzco for the TV Spin Off (as had previously been the case with Many Video Games and for Kuzco's cameo previously in House of Mouse (2001)). Most of the Other VAs from The Emperor's New Groove (2000) (only other exception being John Goodman as Pacha during season 1) reprised their roles of their Respsective Characters)
Patrick Warburton, Eartha Kitt, Wendie Malick and John Goodman are only cast members of the film to reprise their roles in the TV spinoff