'Schadenfreude' is a German word meaning a feeling of pleasure caused by something bad happening to another person.

James Lipton was invited to appear in the film when John Cusack appeared on 'Inside the Actor's Studio.'

Scamper was originally to be introduced while hanging himself as Igor returns to the castle at the beginning of the movie. This is included in the novelization of the film but was cut from the actual release.

Metro-Goldwyn-Mayer's first computer-animated film and first theatrically released animated feature since All Dogs go to Heaven 2 (1996).

Basil Poledouris was originally set to compose the film's musical score during pre-production but died before he could record any music. Although, he composed the music for the Exodus log, another composer, Patrick Doyle, replaced him.

Though MGM was always the distributor of this film, it was originally developed by The Weinstein Company, but they later sold their share of the rights to MGM.

The first fully animated film for Sean Hayes to release theatrically, after previous films of his doing voice over work had been live action films.

Jay Leno (King Malbert) and Eddie Izzard (Dr Schadenfreude) also appeared in Pixar's Cars franchise on separate occasions Leno was in the first film as Jay Limo while Izzard was in the second film as Sir Miles Axelrod, in addition Leno and Izzard would later work together in the DreamWorks Animation film Abominable (2019).

Christian Slater: as one of the other Igors. Slater was the first choice for the lead role of Igor.

The characters "Jaclyn and Heidi" are a subtle reference to Robert Louis Stevenson's "Jekyll and Hyde."