The flashback scene in which Christian Slater is becoming invisible re-uses footage from the original Hollow Man (2000).
When Jack and Maggy are walking on the sidewalk, a man is heard shouting "Bacon is murder!" The part of the homicidal invisible man in the original Hollow Man (2000) was played by Kevin Bacon.
The prescription bottle Frank Turner places on Det Harrison's desk is labeled "Kindasortacyn" and its generic equivalent, "Somethinesleacyn".
The character's name "Michael Griffin" is a direct reference to the character of "Griffin" from H.G. Wells' 1897 serial novel "The Invisible Man". In Wells' story, Griffin was driven insane by his invisibility - much like the character in this movie.