The youngest boy, Sam, is a cross-dresser. In real life, series star and executive producer 'Eddie Izzard' is a transvestite. Sam's choice of clothing was decided by series creator Dmitry Lipkin before Eddie was a part of the show.

The show was originally titled "Low Life", though the name was changed due to creative reasons.

One of two shows that FX greenlighted in 2007 with female lead characters, trying to shake the public conception of the network as a 'male network'. The other show being Dirt.