- This game takes place around the same time that the smoking ban in New York City was first being implemented. One of the characters in-game ignores the law and smokes cigarettes in a bar and numerous characters make dialogue references to this.
- A few of the characters in the game are sometimes shown snorting cocaine. Another one of the characters is nearly always seen smoking a marijuana joint and is said to be a dealer.
- Many missions in the game involve drugs in some way, such as having to blow up a Russian truck that's said to contain heroin, or finding a stolen bag of cocaine. Generally, the drugs are not actually shown on-screen.
- Players can become intoxicated and drive. The game penalizes the player for doing so by making it difficult to steer and drive, and any nearby police will also converge on the player if this attempted. The option to hail a taxi is given, but due to inability to walk properly, it is made very difficult to actually do this, which may lead some players to simply try to drive.