Chris Williams, who plays Wilhelldiva Hater (the drag queen parody of Wilhelmina Slater), is Vanessa Williams' brother.
Silvio Horta revealed in an interview that it was entirely the network's decision to hire Lindsay Lohan on the show, against Horta's own wishes. Lohan was so difficult to work with that even though she signed up for six episodes in season 3, her character was written out after three.
On Betty's nightstand sits a copy of the book The Sisterhood of the Traveling Pants. America Ferrera plays Carmen in the film version of the book.
There was an actual fashion publication titled MODE, geared toward plus-size women. The magazine ceased publication in 2001.
The pearl "B" necklace Betty wears is a replica of the famous necklace worn by Anne Boleyn, Henry VIII's 2nd wife and mother of Elizabeth I.
Mark's name in "Fake Plastic Snow" is Mark Saint-James, but in "Don't Ask Don't Tell," his name is Mark Weiner. (From a deleted scene from "Don't Ask Don't Tell," Betty asks Marc: "Your real name is Weiner?" Marc answers: "I had to change it. A gay kid named Weiner? I wanted to beat myself up.")
The image of the character of Fey Summers is based on that of long time Vogue editor, Anna Wintour.
The Suarez family is from Mexico, but none of the actors are ethnically Mexican. America Ferrera is Honduran, Tony Plana is Cuban, Ana Ortiz is Puerto Rican-Irish, and Mark Indelicato is Puerto Rican-Italian.
Rebecca Romijn left the show because she felt that the new writing staff (after the WGA strike ended in 2008) wrecked her character.
Salma Hayek enjoyed being on set so much that she took advantage of her producer role to get the part of Sofia Reyes.
"Betty la Fea" is the title of the original Colombian soap-opera and its other international spin offs.
Amanda Tanen is named after Brian Tanen, an Ugly Betty production crew member and writer.
In the October 7, 2006, episode of Saturday Night Live (1975) cast member Fred Armisen spoofed the character of Betty by playing a look-alike named Fugly Betsy.
Despite being set in New York and its pilot being filmed there, the first and second seasons were filmed entirely in Los Angeles. Stock footage was used to establish that the show is set in New York. At the beginning of the third season the show relocated back to New York.
Although Alexis is supposed to be Daniel's older sibling, Eric Mabius is actually 19 months older than Rebecca Romijn.
Patricia Field created all of the costumes in the pilot. Field, a resident of New York, left the show when production moved to Los Angeles, but returned as costume designer for the third season, when the show relocated back to New York.
There is always a new decoration decorating the tunnel of Mode Magazine's halls. In the Pilot episode there is nothing on the shelves, but in the last episode there are, what looks like, papermache dolls of characters from the show, including (and best) a doll of Betty Suarez in her iconic poncho.
The house in which the Suarez family live in is not a real house. The inside of the house is a set and the outside is just 1 wall against a green screen to create a fake street with many other homes. This is the case when the show was filmed in Los Angeles, when the show relocated to New York, an actual house in Jackson Heights, Queens was used for the exteriors.
The success of Ugly Betty has inspired a Halloween costume in America after the series' debut.
Although Fashion TV is mentioned in the series, it is not connected to the real-life TV series or the French channel of the same name.
The outside of the modern art museum shown is actually the outside of the New England Aquarium in Boston, with some computer-generated differences.