Wesley Snipes was offered the chance to reprise his role as Blade but declined.

In Comics Scene#46, Lee Goldberg notes that he got involved with an earlier attempt to adapt Blade to television, as a companion series to She-Wolf of London (1990). When the latter series disappointed, Blade got aborted as a TV series. Goldberg also met with Richard Roundtree at a dinner event to see if he would play Blade; they both got food poisoning.

Showtime was originally going to produce the series with Wesley Snipes reprising his famous role as Blade. The series was going to be a loose adaptation of the Blade: The Vampire Hunter comic book series. Katharine Isabelle was going to be a regular in the series, and the character of Karen Jensen from the first film was going to return. Marc Singer was going to be a main character in the series playing Bible John from the comic. But after Snipes turned down the role due to his lawsuit with New Line, Showtime decided not to develop the series.

Actor Sticky Fingas was part of the rap group Onyx. His cousin and former group member Fredro Starr also took to acting and portrayed one of Blade's old friends in the episode "Bloodlines."