Iron Man / Tony Stark (52 episodes, 2009-2012)
James Rhodes / War Machine / James 'Rhodey' Rhodes (50 episodes, 2009-2012)
Pepper Potts / Rescue / Grateful Civilian (49 episodes, 2009-2012)
Iron Man Onboard Computer / Reporter / Gene's Mother (21 episodes, 2009-2012)
Gene Khan / Mandarin / The Mandarin / Xin Zhang (21 episodes, 2009-2012)
Obadiah Stane / Iron Monger (14 episodes, 2009-2012)
Howard Stark (13 episodes, 2009-2012)
Whitney Stane / Madame Masque (13 episodes, 2009-2012)
Roberta Rhodes (11 episodes, 2009-2012)
Justin Hammer / Titanium Man (12 episodes, 2011-2012)
Happy Hogan / Black Knight / Nathan Garrett (11 episodes, 2009-2012)
Nick Fury (9 episodes, 2009-2012)
Maria Hill / Delphi / Technovore / Prof. Benning (6 episodes, 2009-2012)
O'Brian / Makluan Warrior / Teacher / Crimson Dynamo / Stark Security Computer (2 episodes, 2009-2012)
Black Widow / Natasha Romanoff (7 episodes, 2011-2012)
Sasha (7 episodes, 2011-2012)
Fix 2.0 / Mr. Fix / Mister Fix (7 episodes, 2009-2012)
Clint Barton / Hawkeye / Rick Jones / SHIELD Agent (6 episodes, 2009-2012)
Black Panther / T'Challa (2 episodes, 2009-2012)
Ghost / Makluan Warrior / The Beserker (1 episode, 2009-2012)
(4 episodes, 2009-2012)
Tricia (3 episodes, 2009)
Killer Shrike / Simon Maddicks (1 episode, 2009-2012)
Controller / Basil Sandhurst (3 episodes, 2009-2012)
Whiplash / Marc Scarlotti (2 episodes, 2009-2012)
Hulk (1 episode, 2009-2012)
Unicorn / Milos Masaryk (1 episode, 2009-2012)
Blizzard / Donnie Gill (2 episodes, 2009-2012)
M.O.D.O.C. (2 episodes, 2009-2011)
Mean Guard / Police Captain (3 episodes, 2009)
Arthur Parks / Living Laser (3 episodes, 2009)
Rhona Erwin / Mad Thinker (1 episode, 2011)
Erik Lehnsherr / Magneto / Professor Abraham Klein / Professor Charles Xavier (1 episode, 2009-2012)
Count Nefaria / Luchino Nefaria (1 episode, 2009-2012)
Fin Fang Foom / Helicopter Pilot (2 episodes, 2009)
Dr. Peter Corbeau (1 episode, 2009)
Abigail Brand (1 episode, 2009)
Crimson Dynamo / Ivan Vanko (1 episode, 2009)
Arthur Parks / Living Laser (1 episode, 2011)
Nakia (1 episode, 2011)
Gen. Thaddeus 'Thunderbolt' Ross (1 episode, 2012)
Gene Khan / Young (1 episode, 2012)
Doctor Doom / Victor Von Doom (uncredited) (2 episodes, 2011-2012)
Andy Erwin (uncredited) (1 episode, 2011)
Prof. Zimmer (uncredited) (1 episode, 2011)
Andros Stark / Iron Man 2099 (uncredited) (1 episode, 2012)
Jean Grey (uncredited) (1 episode, 2012)
Senator Robert Kelly (uncredited) (1 episode, 2012)