Leonard Hofstadter (279 episodes, 2006-2019)
Sheldon Cooper (279 episodes, 2006-2019)
Penny / Penny Hofstadter (278 episodes, 2007-2019)
Howard Wolowitz (279 episodes, 2007-2019)
Raj Koothrappali (279 episodes, 2007-2019)
Bernadette Rostenkowski (209 episodes, 2009-2019)
Amy Farrah Fowler (203 episodes, 2010-2019)
Stuart Bloom (84 episodes, 2009-2019)
Debbie Wolowitz (39 episodes, 2007-2017)
Barry Kripke / Kripke (25 episodes, 2009-2019)
Emily Sweeney (17 episodes, 2014-2017)
Wil Wheaton (17 episodes, 2009-2019)
Dr. V.M. Koothrappali (16 episodes, 2007-2019)
Dr. Beverly Hofstadter (16 episodes, 2009-2019)
Bert Kibbler (15 episodes, 2013-2019)
Mary Cooper (14 episodes, 2007-2018)
President Siebert (13 episodes, 2011-2019)
Captain Sweatpants (1 episode, 2009-2014)
Priya Koothrappali (12 episodes, 2010-2011)
Zack Johnson (11 episodes, 2010-2019)
Mrs. Koothrappali (10 episodes, 2007-2015)
Halley Wolowitz (10 episodes, 2016-2019)
Leslie Winkle (9 episodes, 2007-2016)
Anu (9 episodes, 2018-2019)
Lucy (8 episodes, 2013-2017)
Denise (8 episodes, 2018-2019)
Stephen Hawking (7 episodes, 2012-2017)
Janine Davis (6 episodes, 2013-2019)
Arthur Jeffries (6 episodes, 2013-2018)
Mike Rostenkowski (6 episodes, 2012-2015)
Colonel Richard Williams (6 episodes, 2016-2017)
Mike Massimino (6 episodes, 2012-2014)
Althea (5 episodes, 2006-2016)
Dr. Eric Gablehauser (5 episodes, 2007-2008)
Wyatt (5 episodes, 2010-2019)
Claire (5 episodes, 2016-2017)
Dimitri (5 episodes, 2012)
Announcer / Man / Lecturer (5 episodes, 2010-2018)
Announcer / Astronaut / Dave Roeger / Headmaster Edwards / Train Conductor (4 episodes, 2008-2015)
Alex Jensen (4 episodes, 2012-2013)
Dr. Stephanie Barnett (3 episodes, 2008)
Kurt (3 episodes, 2007-2009)
LeVar Burton (3 episodes, 2011-2014)
Dave Gibbs (3 episodes, 2015)
Ramona Nowitzki (3 episodes, 2008-2017)
Mrs. Fowler (3 episodes, 2018)
Computer / Automated Cell Phone Voice (3 episodes, 2007-2017)
Ira Flatow (3 episodes, 2009-2017)
Ruchi (3 episodes, 2017)
Guard / Police Officer / Security Guard (3 episodes, 2010-2016)
George Cooper, Jr. (3 episodes, 2018)
Dr. Kevin Campbell (3 episodes, 2019)
Larry Fowler (3 episodes, 2018)
Dr. Greg Pemberton (3 episodes, 2019)
Chen (2 episodes, 2007-2008)
Cheryl (2 episodes, 2007-2008)
Analeigh Tipton / Vanessa Bennett (2 episodes, 2008-2015)
Bethany / Hostess (2 episodes, 2009-2015)
Neil deGrasse Tyson (2 episodes, 2010-2018)
Katee Sackhoff (2 episodes, 2009-2010)
Maria (2 episodes, 2008-2015)
Waiter (2 episodes, 2010-2013)
Glen / Security Guard (2 episodes, 2010-2012)
George Sr. / Jimmy Speckerman (2 episodes, 2011-2018)
Santa (2 episodes, 2012-2014)
Dan (2 episodes, 2014)
Emily (2 episodes, 2011-2017)
Dale (2 episodes, 2011-2013)
Bill Nye (2 episodes, 2013-2018)
Doctor / Man / Minister (2 episodes, 2015)
Mrs. Petrescu (2 episodes, 2016-2018)
Mrs. Fowler / Mrs. Lorvis (2 episodes, 2010-2014)
Jess (2 episodes, 2018-2019)
Dr. George Smoot / George F. Smoot (2 episodes, 2009-2019)
Waiter (2 episodes, 2013-2014)
Kevin Smith (2 episodes, 2015-2019)
Dr. Alfred Hofstadter (2 episodes, 2016)
Dr. Graybel (2 episodes, 2018-2019)
Marissa Johnson (2 episodes, 2019)
Missy Cooper (2 episodes, 2008-2018)
Karen (2 episodes, 2019)
Ellen DeGeneres (1 episode, 2016-2019)
Christy Vanderbilt (1 episode, 2007)
Lalita Gupta (1 episode, 2007)
Charlie Sheen (1 episode, 2008)
Dr. David Underhill (1 episode, 2008)
Toby Loobenfeld (1 episode, 2008)
Octavia (1 episode, 2008)
Mike (1 episode, 2008)
Chinese Leonard (1 episode, 2008)
Summer Glau (1 episode, 2009)
Mikayla (1 episode, 2009)
Dr. Catherine Millstone (1 episode, 2009)
Professor Crawley (1 episode, 2009)
Todd (1 episode, 2009)
FBI Special Agent Angela Page (1 episode, 2010)
Dr. Elizabeth Plimpton (1 episode, 2010)
Stan Lee (1 episode, 2010)
Officer Hackett (1 episode, 2010)
Steve Wozniak (1 episode, 2010)
Venkatesh Koothrappali (1 episode, 2010)
Patty (1 episode, 2007)
Doug (1 episode, 2007)
Charlotte (1 episode, 2008)
Eric (1 episode, 2008)
Dennis Kim (1 episode, 2008)
Jan (1 episode, 2008)
Chinese Sheldon (1 episode, 2008)
Sarah (1 episode, 2009)
Alicia (1 episode, 2009)
Professor Laughlin (1 episode, 2009)
Jeremy (1 episode, 2009)
Denny (1 episode, 2009)
Abby (1 episode, 2010)
Sandy (1 episode, 2010)
Joyce Kim (1 episode, 2010)
Young Man (1 episode, 2010)
Mrs. Latham (1 episode, 2011)
Cole (1 episode, 2012)
Summer (1 episode, 2007)
Waitress (1 episode, 2007)
News Announcer (1 episode, 2008)
Blaine (1 episode, 2008)
Kathy O'Brien (1 episode, 2008)
Model (1 episode, 2008)
Emma (1 episode, 2008)
Dan (1 episode, 2008)
Dmitri (1 episode, 2008)
Lourdes (1 episode, 2008)
Skeeter (1 episode, 2009)
Mildred (1 episode, 2009)
Ground Controller (1 episode, 2009)
Sebastian (1 episode, 2010)
George Takei (1 episode, 2010)
Martha (1 episode, 2010)
Judge J. Kirby (1 episode, 2010)
Glenn (1 episode, 2011)
Kevin (1 episode, 2011)
Dry Cleaner (1 episode, 2012)
Reverend White (1 episode, 2012)
Paramedic (1 episode, 2013)
Dr. Gunderson (1 episode, 2013)
Student (1 episode, 2013)
Jesse (1 episode, 2014)
Yvette (1 episode, 2014)
Dr. Oliver Lorvis (1 episode, 2014)
James Earl Jones (1 episode, 2014)
Mitchell (1 episode, 2015)
Mandy Chow (1 episode, 2015)
Gwen (1 episode, 2015)
Older Indian Man (1 episode, 2015)
Marty (1 episode, 2016)
Issabella (1 episode, 2016)
Andre (1 episode, 2016)
Dr. Robert Wolcott (1 episode, 2018)
Nell (1 episode, 2018)
Vicki (1 episode, 2007)
Instructor (1 episode, 2007)
Stan (1 episode, 2008)
Tom (1 episode, 2008)
Woman (1 episode, 2008)
Rebecca (1 episode, 2009)
Joey (1 episode, 2010)
Mrs. Gunderson (1 episode, 2010)
Louie (1 episode, 2010)
Alice (1 episode, 2011)
Angela (1 episode, 2011)
Sandy (1 episode, 2011)
Laura (1 episode, 2011)
Dr. Bernstein (1 episode, 2011)
Ho-Jun (1 episode, 2011)
Mrs. Rostenkowski (1 episode, 2012)
Siri (1 episode, 2012)
Jonathan (1 episode, 2012)
Buzz Aldrin (1 episode, 2012)
Lakshmi Choudry (1 episode, 2012)
Jimmy (1 episode, 2012)
Phil (1 episode, 2012)
Officer Reynolds (1 episode, 2013)
Lizzy (1 episode, 2013)
Grace (1 episode, 2013)
Pizza Delivery Guy (1 episode, 2013)
Scientist (1 episode, 2013)
Carrie Fisher (1 episode, 2014)
Eric (1 episode, 2014)
Roy (1 episode, 2014)
Flight Attendant (1 episode, 2014)
Nathan (1 episode, 2015)
Chelsea (1 episode, 2015)
Elon Musk (1 episode, 2015)
Trent Monaco (1 episode, 2015)
Security Guard (1 episode, 2015)
Cindy (1 episode, 2015)
Theodore (1 episode, 2016)
Dr. Gallo (1 episode, 2016)
Meemaw (1 episode, 2016)
Doug (1 episode, 2017)
Dr. Sanders (1 episode, 2017)
Clerk (1 episode, 2017)
Oliver (1 episode, 2018)
Young Sheldon (1 episode, 2018)
Neil Gaiman (1 episode, 2018)
Bartender (1 episode, 2018)
Jenna (1 episode, 2018)
Bill Gates (1 episode, 2018)
Kathleen (1 episode, 2018)
Sarah Michelle Gellar (1 episode, 2019)
Joe Manganiello (1 episode, 2019)
Roberta (1 episode, 2007)
Son (1 episode, 2008)
Joy (1 episode, 2010)
Officer Shin (1 episode, 2011)
Elsie (1 episode, 2011)
Dispatcher (1 episode, 2011)
Nurse in Biohazard Suit (1 episode, 2011)
Angelo (1 episode, 2012)
Claire (1 episode, 2012)
Aaron (1 episode, 2012)
Professor Rothman (1 episode, 2012)
Girl #1 (1 episode, 2013)
Woman (1 episode, 2013)
Lana (1 episode, 2013)
Tom (1 episode, 2013)
Dr. Dreyfus (1 episode, 2014)
Ms. Davora (1 episode, 2014)
Salesperson (1 episode, 2014)
Stadium Announcer (1 episode, 2014)
Photographer (1 episode, 2014)
Kenny Fitzgerald (1 episode, 2015)
Tech Support (1 episode, 2015)
Josh Wolowitz (1 episode, 2015)
Travis (1 episode, 2015)
Casting Assistant (1 episode, 2015)
Candidate #1 (1 episode, 2015)
Natalie (1 episode, 2015)
Security Guard #2 (1 episode, 2015)
Trevor (1 episode, 2016)
The Flash (1 episode, 2016)
Tim (1 episode, 2016)
Five Year Old (1 episode, 2016)
Rebecca (1 episode, 2017)
Police Officer (1 episode, 2017)
Danielle (1 episode, 2017)
Man (1 episode, 2017)
Stranger (1 episode, 2017)
Dr. Lee (1 episode, 2018)
Marta (1 episode, 2018)
Dr. Park (1 episode, 2018)
Marcus (1 episode, 2018)
Tam Nguyen (1 episode, 2018)
Nicholas (1 episode, 2018)
Pit Boss (1 episode, 2018)
Margaret (1 episode, 2018)
Danny (1 episode, 2019)
Todd Zarnecki (1 episode, 2011)
Brian Greene (1 episode, 2011)
Dr. Schneider (1 episode, 2012)
Jeremy (1 episode, 2012)
Girl #2 (1 episode, 2013)
Car Thief #1 (1 episode, 2013)
Kenneth (1 episode, 2014)
Jeanie (1 episode, 2014)
Professor Sharpe (1 episode, 2014)
Officer Hernandez (1 episode, 2014)
Maria (1 episode, 2014)
Wardrobe Person (1 episode, 2014)
Voicemail (1 episode, 2014)
Zombie (1 episode, 2015)
Grace (1 episode, 2015)
Candidate #2 (1 episode, 2015)
Adam Nimoy (1 episode, 2015)
Tech Support Recording (1 episode, 2015)
Hostess (1 episode, 2015)
Moviegoer (1 episode, 2015)
Caller (1 episode, 2015)
Alien (1 episode, 2015)
Receptionist (1 episode, 2015)
Nolan (1 episode, 2016)
Ainsley (1 episode, 2016)
Glenn the Maitre D' (1 episode, 2016)
Dr. Harris (1 episode, 2017)
Denise (1 episode, 2017)
Nurse (1 episode, 2017)
Rose Lady (1 episode, 2017)
Georgie (1 episode, 2018)
Mark Hamill (1 episode, 2018)
Wendell (1 episode, 2018)
Letty (1 episode, 2018)
Andrea (1 episode, 2018)
Grant (1 episode, 2018)
Toby (1 episode, 2018)
Croupier (1 episode, 2018)
Nathan (1 episode, 2019)
Bebe (1 episode, 2019)
Kareem Abdul-Jabbar (1 episode, 2019)
Maritza (1 episode, 2019)
King of Sweden (1 episode, 2019)
Lillian (1 episode, 2012)
Joan (1 episode, 2012)
Gretchen (1 episode, 2013)
Car Thief #2 (1 episode, 2013)
Justin (1 episode, 2013)
Travis (1 episode, 2014)
Man (1 episode, 2014)
Attractive Red Head (1 episode, 2015)
Candidate #3 (1 episode, 2015)
Alien #2 (1 episode, 2015)
Susan (1 episode, 2016)
Adam West (1 episode, 2016)
Daniel (1 episode, 2016)
Customer (1 episode, 2016)
Dr. Zane (1 episode, 2017)
Sunny Morrow (1 episode, 2018)
Cynthia (1 episode, 2018)
Waiter (1 episode, 2018)
Hostess (1 episode, 2018)
Colin (1 episode, 2018)
Judge #1 (1 episode, 2018)
Greg (1 episode, 2018)
Mitch (1 episode, 2019)
Neil (1 episode, 2019)
Andy (1 episode, 2019)
Cynthia (1 episode, 2019)
Woman #1 (1 episode, 2019)
Terry (1 episode, 2019)
Halley Wolowitz (1 episode, 2019)
Greg (1 episode, 2019)
Russian Mission Control (1 episode, 2012)
Chauffeur (1 episode, 2012)
Guy (1 episode, 2013)
Marta (1 episode, 2014)
Woman (1 episode, 2014)
Christopher (1 episode, 2016)
Leslie (1 episode, 2018)
Bellman (1 episode, 2018)
Earl (1 episode, 2018)
William Shatner (1 episode, 2015-2019)
Brenda (1 episode, 2019)
Kwame (1 episode, 2019)
Linda (1 episode, 2019)
Michael Wolowitz (1 episode, 2019)
Woman #2 (1 episode, 2019)
Chad (1 episode, 2019)
Older Gentleman (1 episode, 2014)
Randall (1 episode, 2016)
Jeff (1 episode, 2016)
Tour Guide (1 episode, 2018)
Darren (1 episode, 2019)
Woman #3 (1 episode, 2019)
Woman (1 episode, 2019)
Announcer (1 episode, 2019)
Woman #4 (1 episode, 2019)
Frances H. Arnold (1 episode, 2019)
Kip Thorne (1 episode, 2019)
Woman #5 (1 episode, 2019)
Woman #6 (1 episode, 2019)
Woman #7 (1 episode, 2019)
Woman #8 (1 episode, 2019)
Little Girl (1 episode, 2019)
Beautiful Young Woman (1 episode, 2014)
Reporter #1 (1 episode, 2019)
Reporter #2 (1 episode, 2019)
Reporter #3 (1 episode, 2019)
Lonely Larry (uncredited) (7 episodes, 2009-2013)
Comic Book Store Customer / Bachelor Party Attendee / Member of Wil Wheaton's Entourage / Wil Wheaton Party Guest (uncredited) (5 episodes, 2010-2013)
Cafeteria Patron / Cafeteria Patron in Star Trek Uniform (uncredited) (3 episodes, 2013-2018)
Cafeteria Patron / Restaurant Patron (uncredited) (2 episodes, 2010)
Assoc. Professor (uncredited) (2 episodes, 2010)
Ballroom Dancer / Professor (uncredited) (2 episodes, 2011)
Cafeteria Patron (uncredited) (2 episodes, 2013)
Reception Guest / Train Station Passenger (uncredited) (2 episodes, 2014-2019)
Comic Book Store Patron / Comic Con Patron (uncredited) (2 episodes, 2015-2016)
Gilda (uncredited) (1 episode, 2006)
Katie (uncredited) (1 episode, 2006)
Delivery Man (uncredited) (1 episode, 2007)
Professor Goldfarb (uncredited) (1 episode, 2008)
Chinese International Grad Student (uncredited) (1 episode, 2008)
Kid Playing Guitar (uncredited) (1 episode, 2008)
Mike (uncredited) (1 episode, 2009)
Raj's Bar Lady (uncredited) (1 episode, 2009)
Singer (uncredited) (1 episode, 2010)
Brawny Inmate (uncredited) (1 episode, 2010)
Girl in Line at Park (uncredited) (1 episode, 2010)
Woman (uncredited) (1 episode, 2010)
Gorn (uncredited) (1 episode, 2010)
Janet Hill (uncredited) (1 episode, 2010)
Extra (uncredited) (1 episode, 2010)
Jedi (uncredited) (1 episode, 2010)
Movie Goer (uncredited) (1 episode, 2010)
Professor (uncredited) (1 episode, 2011)
Brent Spiner (uncredited) (1 episode, 2011)
Ricky the Smoking Monkey (uncredited) (1 episode, 2011)
Wealthy Benefactor (uncredited) (1 episode, 2011)
Movie Goer (uncredited) (1 episode, 2011)
Waiter (uncredited) (1 episode, 2011)
Bollywood Dancer (uncredited) (1 episode, 2011)
Cheesecake Factory Diner (uncredited) (1 episode, 2011)
Mr. Spock (uncredited) (2 episodes, 2012-2015)
Howie Mandel (uncredited) (1 episode, 2012)
Guy at the Movies (uncredited) (1 episode, 2012)
Guy in Club (uncredited) (1 episode, 2012)
Bachelor Party Attendee (uncredited) (1 episode, 2012)
Paramedic #1 (uncredited) (1 episode, 2013)
Matt (uncredited) (1 episode, 2013)
Cafeteria Student (uncredited) (1 episode, 2013)
Cheesecake Factory Patron (uncredited) (1 episode, 2013)
Eye Rolling Girl Student (uncredited) (1 episode, 2013)
Library Graduate Student (uncredited) (1 episode, 2013)
Waitress (uncredited) (1 episode, 2013)
Party Guest (uncredited) (1 episode, 2013)
Employee (uncredited) (1 episode, 2013)
Drunk Scientist (uncredited) (1 episode, 2013)
Robby The Robot (uncredited) (1 episode, 2014)
Bar Patron (uncredited) (1 episode, 2014)
Mini Bernadette (uncredited) (1 episode, 2014)
Cafeteria Patron (uncredited) (1 episode, 2014)
Comic Book Customer (uncredited) (1 episode, 2014)
Professor in Cafeteria (uncredited) (1 episode, 2014)
Airport Pedestrian (uncredited) (1 episode, 2015)
Audition Girl (uncredited) (1 episode, 2015)
Employee (uncredited) (1 episode, 2017)
Bar Patron (uncredited) (1 episode, 2017)
Cafeteria Patron (uncredited) (1 episode, 2017)
Airline Passenger (uncredited) (1 episode, 2017)
Comic Con Collector (uncredited) (1 episode, 2017)
Comic Book Store Background (uncredited) (1 episode, 2017)
Will's +1 (uncredited) (1 episode, 2018)
Wedding Guest in Red Dress (uncredited) (1 episode, 2018)
Dead Detective (uncredited) (1 episode, 2018)
Guy in Comic Book Store (uncredited) (1 episode, 2018)
Male Planetarium Goer (uncredited) (1 episode, 2018)
Family Member Wedding Guest (uncredited) (1 episode, 2018)
Tour Group Member (uncredited) (1 episode, 2018)
Assistant Football Coach (uncredited) (1 episode, 2018)
Cafe Patron (uncredited) (1 episode, 2018)
Judge #2 (uncredited) (1 episode, 2018)
Women in Audience (uncredited) (1 episode, 2019)
Bob (uncredited) (1 episode, 2019)
News Reporter (uncredited) (1 episode, 2019)
Prince Daniel (uncredited) (1 episode, 2019)
Tuxedoed Guest (Laureate) (uncredited) (1 episode, 2019)