- Brian O'Conner, back working for the FBI in Los Angeles, teams up with Dominic Toretto to bring down a heroin importer by infiltrating his operation.
- Heading back to the streets where it all began, two men rejoin two women to blast muscle, tuner and exotic cars across Los Angeles and floor through the Mexican desert. When a crime brings them back to L.A., fugitive ex-con Dom Toretto reignites his feud with agent Brian O'Connor. But as they are forced to confront a shared enemy, Dom and Brian must give in to an uncertain new trust if they hope to outmaneuver him. And from convoy heists to precision tunnel crawls across international lines, two men will find the best way to get revenge: push the limits of what's possible behind the wheel.—Universal Studios
- Dominic Toretto, street racer-thief who's still wanted by both the law and some criminals he has crossed, decides to cut himself from everyone close to him including his girlfriend Letty. Later he learns Letty was killed in L.A. so he returns to find out what happened. Brian Conner, an undercover cop allowed Dom to escape instead of turning him in, now works for the FBI. He's been searching for a elusive drug dealer known as Braga. His trail leads him to the same man that Dom is looking for. It seems that Letty was working as a courier for Braga. When Braga searches for some new drivers, Dom and Brian put themselves forward. Dom wants to get to the man who killed Letty while Brian is looking for Braga.—rcs0411@yahoo.com
- Dominic (Vin Diesel) and his new crew (Letty (Michelle Rodriguez), Han (Sung Kang), Tego Leo (Tego Calderon), Santos (Don Omar) and Cara) are hijacking fuel tankers in the Dominican Republic. They attack an oil tanker train. Dom position his car in front of the tanker train to control its speed. Letty gets onto the tanker train and detaches the last 2 oil tanks, while Han harnesses his car to the detached oil tanks and veers them away. Then Tego and Santos move their car into position to take the next 2 oil tanks. But this time the driver of the tanker train sees them. He pushes through Dom, throwing Letty off balance.
Santos and Tego are not able to unhitch, so Dom asks Letty to spray the tanker coupling with a freezing compound. As she lost her hammer, Dom crashes his car into the tanker train to detach the next 2 tanks. Santos and Tego drive away, but Letty is still on the tanker train and the train heads into a steep downward incline. The driver jumps away, leaving Dom to save Letty. Letty jumps on the hood of Dom's car, but the tanker train goes out of control and overturns, leading to Dom timing his car in a way that he drives under the last tank that was bouncing towards him, before exploding.
Dominic begins to suspect the trail is too hot (as cops had just raided his garage in Baracoa) and leaves Letty behind in order to protect her from harm as the authorities only want Dom. Dom pays off Han with his share and asks him to do his own thing.
Several weeks later, in Panama City, Dominic gets a call from Mia (Jordana Brewster), who tells him that Letty has been murdered by Fenix Calderon (Laz Alonzo), after getting into a near fatal car accident. Dominic heads back to Los Angeles to examine Letty's crash and finds traces of Nitromethane in the burn marks on the ground. He then goes to the only car mechanic that uses Nitromethane and coerces him into giving him the name David Park (Ron Yuan), the man who ordered the fuel.
Meanwhile, F.B.I. agent Brian O'Conner is trying to track down a drug dealer named Arturo Braga (John Ortiz). His search leads him to David Park, a scout for Braga, looking for skilled drivers who can work for Braga. Braga has moved more heroine into US than Escobar did in 10 years. And the 3 previous agents sent to apprehend him came back in body bags. Brian is confident that without drivers, Braga cannot more his merchandise into US.
As soon as Dom arrived in the US, FBI's facial recognition software picked him up and Brian was informed about it.
Dominic arrives at Park's apartment first and hangs him out of the window by his ankles before letting go. Brian, who was also on his way to Park's place, saves Park and Park becomes the FBI's new informant. Park gets Brian into a street race through Los Angeles.
Brian selects a modified Nissan Skyline GT-R R34 from the Impound Lot. Dominic also shows up to race in his modified 1970 Chevrolet Chevelle. Gisele Yashar (Gal Gadot), the liaison for Braga, reveals that the winner will become the last driver on a team that traffics heroin between the United States-Mexico border. Dominic wins by bumping Brian's car, making him lose control. Brian uses his power as an FBI agent to arrest another driver, Dwight Mueller (Greg Cipes), and takes his place on the team.
The following day, the team meets up with Braga's henchman, Fenix, and Dom notices that Fenix drives the same Torino the mechanic described. They drive across the border using underground tunnels to avoid detection. Brian had prior knowledge that, after the heroin was delivered, Braga ordered the drivers to be killed. However, it was revealed to Dominic from Fenix that he killed Letty and after a tense stand-off, Dominic detonates his car with Nitrous to distract Braga's men and Brian hijacks a Hummer with US$ 60 million worth of heroin.
Both Dominic and Brian drive back to Los Angeles and hide the heroin in a police impound lot where Brian picks up a modified Subaru Impreza WRX STI. Later on, Dominic finds out Brian was the last person to contact Letty, which results in him being attacked by Dominic until he learns Letty was working undercover for Brian, tracking down Braga in exchange for clearing Dominic's name.
Brian tells his superiors that in exchange for Dominic's pardon, he will lure Braga into a trap, forcing him to personally show up to exchange money for the heroin. At the drop site, however, Ramon Campos (Robert Miano), the man who claims to be "Braga", is revealed as a decoy, and "Campos", the real Braga, escapes and flees to Mexico with Fenix. In the ensuing chaos, Fenix nearly runs over Gisele before Dom saves her. The failed trap results in Brian being taken off active duty.
Brian and Dominic travel to Mexico on their own to catch Braga. They find him at a church and apprehend him. As Braga's henchmen come down to rescue their leader, Brian and Dominic drive through the underground tunnels back to the United States. When some of Braga's men are killed, Brian crashes his car and is injured after being T-boned by Fenix at the end of the tunnel.
Before Fenix can kill Brian, Dominic, who survived the explosion and exchanged his 1970 Dodge Charger with a 1973 Chevrolet Camaro, drives into and kills Fenix. As police and helicopters start streaming to the crash site on the USA side, Brian tells Dominic to leave, but Dominic refuses, saying he's tired of running.
Despite Brian's request for clemency, the judge sentences Dominic to 25 years to life. Brian resigns from the FBI and Dominic boards a prison bus that will take him to Lompoc penitentiary and as the bus drives down the road, Brian and Mia, along with Leo and Santos (who assisted in the Dominican Republic heists), arrive in their cars to intercept it.
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