Both Jaume Balagueró and Paco Plaza -directors of the original movie [Rec] (2007)- have expressed their big dissatisfaction with this movie.
In October 2008 Knott's Berry Farm theme park in Buena Park, California, had a Quarantine-themed walk-through "maze" for the park's 36th annual Knott's Scary Farm Halloween Haunt. It was their third movie-themed Halloween Haunt maze, after Beowulf (2007) and The Grudge 2 (2006).
It took 4 hours for Doug Jones to get into his full-body prosthetic. His role required him to film for just one day.
Remake of [Rec] (2007). [Rec] 2 (2009) was filmed in the same building, but Quarantine 2: Terminal (2011) wasn't filmed in the same building, but in a plane and in an abandoned building.