Cole looks significantly older than in the original (even though the events take place two years later). This is because even though the original was released in 2017, The Babysitter (2017) was filmed in 2015, The Babysitter: Killer Queen (2020) was filmed in late 2019.

There are two Star Trek references: when Phoebe is going through her 'flip book' in class, it says "Star Trek: Picard (2020) Picard 1- 0 Alien." Later when John is taking to Melanie on the dock, the boat behind him says "Spock."

Shot from October 14, 2019 - November 24, 2019 (41 days).

When Phoebe sits down at the desk next to Cole, you can see she has a tattoo of a black cat on her left wrist. Bee has the same tattoo on her right wrist.

There's a Wilhelm scream at the end of the interpretive sex scene when a man is shot out of a cannon.

There's several The Terminator (1984) references throughout the film. Phoebe and Cole use Terminator 2: Judgment Day (1991) as a reference point, and Melanie states that Cole is a Terminator fan and will be back. The Babysitter and Terminator series both feature the original's antagonist returning as a protector of the main character in the sequel. McG also directed Terminator Salvation (2009).

The idea of a deflowered virgin foiling a demonic triumph was also part of the climax in Cast a Deadly Spell (1991).

At the end of the movie when the members of the Bee's group are about to die, the accompanying music is 'Killer Queen' by Queen. In 'The Babysitter,' as Cole prepares to dispatch Bee, the music playing is 'We are the Champions', also by Queen.