Adult film star Ron Jeremy was not originally supposed to be in the porn actors strike in the film. He had assumed that the directors merely forgot to call him and showed up on set. As a result, all of his dialogue was improvised
In the scene where Chelios runs into a mob of porn stars, the "extras" in the movie are real porn stars. One of the stars most recognizable is Jenna Haze, but Peter North, Lexington Steele, and Ron Jeremy make an appearance as well.
One of Corey Haim's final acting roles before his death on March 10, 2010 and also David Carradine's final acting roles before his death on June 3, 2009.
The artificial heart shown in the movie is actually a real artificial heart, the AbioCor from Abiomed. However the real artificial heart is totally internal and does not include a battery box as shown in the movie. The latest AbioCors can run on battery without recharging (done via external RF chargers) for over 4 hours.
While the theatrical release for the movie has no numeral in the title, the DVD and Blu-Ray releases both are entitled "Crank 2: High Voltage".
When asked about the sex scene on the racetrack, Amy Smart said "Jason (Statham) and I are lying in the middle of a racetrack, with horses galloping past and racing fans loving every minute. I tried not to think of what was in the dirt that we were rolling around in or I would have been sick. It was definitely stinky at times."
The Concerned Man who is seen very briefly asking Chelios if he's okay is played by UFC mixed martial artist Keith Jardine. Jardine is wearing a shirt that says "MEAN 1". This is appropriate as Jardine's in-ring nickname is "The Dean Of Mean".
Cameo: Stephen Graham, Jason Statham buddy in "Snatch" can be seen as a customer in the striptease bar where Chev finds Eve dancing. He seems to be wearing the same characteristic coat as in "Snatch".
When Chev breaks the battery pack to his artificial heart towards the beginning of the movie, the circuit board shown is from a USB hub.
There is a scene where Chev Chelios attempts to shoot a man cowering on the floor, and when he pulls the trigger and finds the gun empty, utters the line "you lucky bastard!". The same scenario also appears in Snatch (2000), which also stars Jason Statham, only the antagonist in that scene is Vinnie Jones.
The Honda Civic used in the backwards carpark spiral-driving has a vinyl wrap that replicates the Nissan Skyline R34, appearing in 2 Fast 2 Furious, driven by Brian O'Conner
Both Dwight Yoakam and Maynard James Keenan appear in this film. Yoakam previously replaced Keenan in the role of Raoul in Panic Room (2002).
Just before Chelios rips open the sidewalk electrical box, you can see the 5-star "Obey" logo popularized by Shepard Fairey, the artist who drew the emblematic "Hope" poster of Obama. Fairey got his artistic start with graffiti and by putting up stickers like Obey all over urban landscapes.
Chester Bennington: The tattooed man Jason Statham rubs up against at the horse track is the lead singer for Linkin Park. He also appeared briefly in the original film as the guy in the hospital pharmacy who tells Chelios about the nasal spray.
Maynard James Keenan: The man with the control to the electric shock collar is the lead singer of prog-metal band Tool.